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BRENDA support

Ligand reduced flavodoxin

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Basic Ligand Information

Molecular Structure
Picture of reduced flavodoxin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C12H11N4O2R
reduced flavodoxin
Synonyms:
4a,5-reduced flavin, dihydroflavodoxin, flavin hydroquinone, flavodoxin semiquinone, reduced electron-transfer flavoprotein, reduced electron-transferring-flavoprotein, reduced electron-transferring flavoprotein, reduced electron transfer flavoprotein, reduced electron transfer flavoprotein, reduced electron transferring flavoprotein, reduced flavin, reduced flavoprotein, [reduced flavodoxin], [reduced NADH-hemoprotein reductase], [reduced NADPH---hemoprotein reductase], [reduced NADPH-hemoprotein reductase], [reduced NADPH.hemoprotein reductase], [reduced NADPH hemoprotein reductase]
Pathway Source
Pathways
BRENDA
(S)-reticuline biosynthesis, aflatoxin biosynthesis, alanine metabolism, androgen and estrogen metabolism, arachidonate biosynthesis more
MetaCyc
(8E,10E)-dodeca-8,10-dienol biosynthesis, 2-methyl-branched fatty acid beta-oxidation, 7,8-dimethylmenaquinone biosynthesis, 8-amino-7-oxononanoate biosynthesis II, 8-methylmenaquinone biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for reduced flavodoxin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (370 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-hydroxybenzoate + [reduced NADPH-hemoprotein reductase] + O2 = 3,4-dihydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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benzylamine + [reduced NADPH-hemoprotein reductase] + O2 = benzylamine N-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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dihydrochelirubine + [reduced NADPH-hemoprotein reductase] + O2 = 12-hydroxydihydrochelirubine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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vinorine + [reduced NADPH-hemoprotein reductase] + O2 = vomilenine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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alpha-humulene + O2 + [reduced NADPH-hemoprotein reductase] = 10-hydroxy-alpha-humulene + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2 = 6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
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dammarenediol-II + [reduced NADPH-hemoprotein reductase] + O2 = protopanaxadiol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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protopanaxadiol + [reduced NADPH-hemoprotein reductase] + O2 = protopanaxatriol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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ent-sandaracopimaradien-3beta-ol + [reduced NADPH-hemoprotein reductase] + O2 = oryzalexin E + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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ent-sandaracopimaradien-3beta-ol + [reduced NADPH-hemoprotein reductase] + O2 = oryzalexin D + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 = 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
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monacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 = monacolin J acid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 = juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 = juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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dodecanoate + [reduced NADPH-hemoprotein reductase] + O2 = 7-hydroxydodecanoate + [oxidized NADPH-hemoprotein reductase] + H2O
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(-)-5'-demethoxyyatein + [reduced NADPH-hemoprotein reductase] + O2 = (-)-5'-demethylyatein + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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1,8-cineole + [reduced NADPH-hemoprotein reductase] + O2 = 2-endo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
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10-deoxysarpagine + [reduced NADPH-hemoprotein reductase] + O2 = sarpagine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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lithocholate + [reduced NADPH-hemoprotein reductase] + O2 = 6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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8-dimethylallylnaringenin + [reduced NADPH-hemoprotein reductase] + O2 = leachianone G + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2 = (+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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abietadiene + [reduced NADPH-hemoprotein reductase] + O2 = abietadienol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2 = 18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(+)-columbianetin + [reduced NADPH-hemoprotein reductase] + O2 = angelicin + acetone + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(+)-valencene + [reduced NADPH-hemoprotein reductase] + O2 = alpha-nootkatol + beta-nootkatol + [oxidized NADPH-hemoprotein reductase] + H2O
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(S)-beta-macrocarpene + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = zealexin A1 + 4 H2O + 3 [oxidized NADPH-hemoprotein reductase]
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(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
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(S)-1-hydroxy-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 = (13S,14R)-1,13-dihydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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fraxetin + [reduced NADPH-hemoprotein reductase] + O2 = sideretin (reduced form) + [oxidized NADPH-hemoprotein reductase] + H2O
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indole-3-carbonyl nitrile + [reduced NADPH-hemoprotein reductase] + O2 = 4-hydroxyindole-3-carbonyl nitrile + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
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(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 = (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 = eupatolide + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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squalene + [reduced NADPH-hemoprotein reductase] + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 = 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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beta-amyrin + [reduced NADPH-hemoprotein reductase] + O2 = 16alpha-hydroxy-beta-amyrin + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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geranylhydroquinone + [reduced NADPH-hemoprotein reductase] + O2 = 3''-hydroxygeranylhydroquinone + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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a C28 steroid + [reduced NADPH-hemoprotein reductase] + O2 = a (22S)-22-hydroxy-C28-steroid + [oxidized NADPH-hemoprotein reductase] + H2O
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cholesterol + [reduced NADPH-hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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a long-chain acyl-[acyl-carrier protein] + reduced flavodoxin + O2 = pimeloyl-[acyl-carrier protein] + an n-alkanal + oxidized flavodoxin + H2O
show the reaction diagram
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12-hydroxyjasmonoyl-L-isoleucine + [reduced NADPH-hemoprotein reductase] + O2 = 12-hydroxy-12-oxojasmonoyl-L-isoleucine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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phenylacetate + [reduced NADPH-hemoprotein reductase] + O2 = (2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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quinine + [reduced NADPH-hemoprotein reductase] + O2 = 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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albendazole + [reduced NADPH-hemoprotein reductase] + O2 = 4'-hydroxyalbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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fenbendazole + [reduced NADPH-hemoprotein reductase] + O2 = hydroxyfenbendazole + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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7-deoxyloganin + [reduced NADPH-hemoprotein reductase] + O2 = loganin + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(6aR,11aR)-3,9-dihydroxypterocarpan + [reduced NADPH-hemoprotein reductase] + O2 = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(S)-cis-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 = allocryptopine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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protopine + [reduced NADPH-hemoprotein reductase] + O2 = 6-hydroxyprotopine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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coniferaldehyde + [reduced NADPH-hemoprotein reductase] + O2 = 5-hydroxyconiferaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(S)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 = (S)-corytuberine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
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2-(L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + [reduced NADPH-hemoprotein reductase] + O2 = camalexin + hydrogen cyanide + CO2 + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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2 (S)-N-methylcoclaurine + 2 (R)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 = berbamunine + guattegaumerine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 = salutaridine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-canadine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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cyclo(L-tyrosyl-L-tyrosyl) + [reduced NADPH-hemoprotein reductase] + O2 = mycocyclosin + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
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tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2 = fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(-)-matairesinol + [reduced NADPH-hemoprotein reductase] + O2 = (-)-pluviatolide + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin
show the reaction diagram
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crotonobetainyl-CoA + reduced electron-transfer flavoprotein = gamma-butyrobetainyl-CoA + electron-transfer flavoprotein
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nitrate + reduced flavodoxin = nitrite + oxidized flavodoxin + H2O
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2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + anaerobilin + Fe2+ + 2 oxidized flavodoxin
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (30 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-2-hydroxyglutarate + electron transfer flavoprotein = 2-oxoglutarate + reduced electron transfer flavoprotein
show the reaction diagram
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(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin
show the reaction diagram
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(2S)-methylsuccinyl-CoA + electron-transfer flavoprotein = 2-methylfumaryl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
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isovaleryl-CoA + electron-transfer flavoprotein = 3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
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sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein
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S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (1116 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ethylbenzene + [reduced NADPH-hemoprotein reductase] + O2 = cis-2,3-dihydroxy-1-ethyl-cyclohexa-4,6-diene + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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3-hydroxybenzoate + [reduced NADPH-hemoprotein reductase] + O2 = 3,4-dihydroxybenzoate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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benzylamine + [reduced NADPH-hemoprotein reductase] + O2 = benzylamine N-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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dihydrosanguinarine + [reduced NADPH-hemoprotein reductase] + O2 = 10-hydroxydihydrosanguinarine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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dihydrochelirubine + [reduced NADPH-hemoprotein reductase] + O2 = 12-hydroxydihydrochelirubine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-3'-hydroxy-N-methylcoclaurine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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vinorine + [reduced NADPH-hemoprotein reductase] + O2 = vomilenine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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3-hydroxyindolin-2-one + [reduced NADPH-hemoprotein reductase] + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + [reduced NADPH-hemoprotein reductase] + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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ent-cassa-12,15-diene + [reduced NADPH-hemoprotein reductase] + O2 = 11-(S)-hydroxy-entcassa-12,15-diene + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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alpha-humulene + O2 + [reduced NADPH-hemoprotein reductase] = 10-hydroxy-alpha-humulene + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2 = 6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
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dammarenediol-II + [reduced NADPH-hemoprotein reductase] + O2 = protopanaxadiol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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protopanaxadiol + [reduced NADPH-hemoprotein reductase] + O2 = protopanaxatriol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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ent-sandaracopimaradien-3beta-ol + [reduced NADPH-hemoprotein reductase] + O2 = oryzalexin E + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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monacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 = monacolin J acid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 = juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(-)-5'-demethoxyyatein + [reduced NADPH-hemoprotein reductase] + O2 = (-)-5'-demethylyatein + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(-)-4'-demethyl-deoxypodophyllotoxin + [reduced NADPH-hemoprotein reductase] + O2 = (-)-4'-demethylepipodophyllotoxin + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + [reduced NADPH-hemoprotein reductase] + O2 = glyceollin + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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10-deoxysarpagine + [reduced NADPH-hemoprotein reductase] + O2 = sarpagine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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lithocholate + [reduced NADPH-hemoprotein reductase] + O2 = 6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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16alpha-hydroxytestosterone + 3 O2 + 3 reduced flavoprotein = (16alpha,17beta)-estra-1(10),2,4-triene-3,16,17-triol + formate + 4 H2O + 3 oxidized flavoprotein
show the reaction diagram
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8-dimethylallylnaringenin + [reduced NADPH-hemoprotein reductase] + O2 = leachianone G + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2 = (+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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abietadiene + [reduced NADPH-hemoprotein reductase] + O2 = abietadienol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2 = 18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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indole + [reduced NADPH-hemoprotein reductase] + O2 = indolin-2-one + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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L-tryptophan + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 = (E)-indol-3-ylacetaldoxime + 2 [oxidized NADPH-hemoprotein reductase] + CO2 + 3 H2O
show the reaction diagram
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(S)-1-hydroxy-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 = (13S,14R)-1,13-dihydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-1-hydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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squalene + [reduced NADPH-hemoprotein reductase] + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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beta-amyrin + [reduced NADPH-hemoprotein reductase] + O2 = 16alpha-hydroxy-beta-amyrin + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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geranylhydroquinone + [reduced NADPH-hemoprotein reductase] + O2 = 3''-hydroxygeranylhydroquinone + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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C30:0 fatty acid + [reduced NADPH-hemoprotein reductase] + O2 = C30:0 omega-hydroxy fatty acid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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castasterone + O2 + [reduced NADPH-hemoprotein reductase] = brassinolide + 2 H2O + [oxidized NADPH-hemoprotein reductase]
show the reaction diagram
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