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Ligand acetaldehyde

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Basic Ligand Information

Molecular Structure
Picture of acetaldehyde (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H4O
acetaldehyde
IKHGUXGNUITLKF-UHFFFAOYSA-N
Synonyms:
acetylaldehyde, Ethanal, ethanaldehyde

Related pathways

Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for acetaldehyde

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetaldehyde + NADH + H+ = ethanol + NAD+
show the reaction diagram
-
acetaldehyde + NADPH + H+ = ethanol + NADP+
show the reaction diagram
-
acetaldehyde + ubiquinol = ethanol + ubiquinone
show the reaction diagram
-
acetaldehyde + NADP+ + H2O = succinate + NADPH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
4-nitrocyclohexan-1-one + acetaldehyde = ?
show the reaction diagram
-
pyruvate + acetaldehyde = acetoin + CO2
show the reaction diagram
-
formate + acetaldehyde = lactate
show the reaction diagram
-
D-Glyceraldehyde 3-phosphate + acetaldehyde = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (50 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ethanol + NAD+ = acetaldehyde + NADH
show the reaction diagram
-
ethanol + NADP+ = acetaldehyde + NADPH + H+
show the reaction diagram
-
ethanol + NAD+ = ethanal + NADH
show the reaction diagram
-
ethanol + NAD(P)+ = acetaldehyde + NAD(P)H + H+
show the reaction diagram
-
ethanol + ferricytochrome c550 = acetaldehyde + ferrocytochrome c550
show the reaction diagram
-
ethanol + O2 = acetaldehyde + H2O2
show the reaction diagram
-
ethanol + N,N-dimethyl-4-nitrosoaniline = acetaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
show the reaction diagram
-
isoeugenol + O2 = vanillin + acetaldehyde
show the reaction diagram
-
17alpha-Hydroxypregnenolone = Dehydroepiandrosterone + acetaldehyde
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetate + H+ + reduced ferredoxin = acetaldehyde + H2O + oxidized ferredoxin
show the reaction diagram
-
ethylamine + H2O + O2 = acetaldehyde + NH3 + H2O2
show the reaction diagram
-
3-hydroxybutan-2-one + D-ribose 5-phosphate = acetaldehyde + 1-deoxy-D-altro-heptulose 7-phosphate
show the reaction diagram
-
(RS)-1-phenylethanol + vinyl acetate = (R)-1-phenylethyl acetate + acetaldehyde + (S)-1-phenylethanol
show the reaction diagram
-
(24R,241R)-fucosterol epoxide = desmosterol + acetaldehyde
show the reaction diagram
-
2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
show the reaction diagram
-
D-threonine = glycine + acetaldehyde
show the reaction diagram
-
L-Thr = glycine + acetaldehyde
show the reaction diagram
-
L-allo-threonine = glycine + acetaldehyde
show the reaction diagram
-
7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
show the reaction diagram
-
acetylene + H2O = acetaldehyde
show the reaction diagram
-
3-(methylthio)acryloyl-CoA + 2 H2O = acetaldehyde + methanethiol + CoA + CO2
show the reaction diagram
-
ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate
show the reaction diagram
-
ethanolamine = acetaldehyde + NH3
show the reaction diagram
-
choline = trimethylamine + acetaldehyde
show the reaction diagram
-
2-hydroxyethane-1-sulfonate = acetaldehyde + H+ + sulfite
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (314 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetaldehyde + NADPH + H+ = ethanol + NADP+
show the reaction diagram
-
acetaldehyde + NADPH + H+ = ethanol + NADP+
show the reaction diagram
-
acetaldehyde + NADH + H+ = ethanol + NAD+
show the reaction diagram
-
acetaldehyde + NADPH + H+ = ethanol + NADP+
show the reaction diagram
-
acetaldehyde + NADPH + H+ = ethanol + NADP+
show the reaction diagram
-
acetaldehyde + NADPH + H+ = ethanol + NADP+
show the reaction diagram
-
acetaldehyde + NADH + H+ = ethanol + NAD+
show the reaction diagram
-
acetaldehyde + NADH + H+ = ethanol + NAD+
show the reaction diagram
-
acetaldehyde + NADPH + H+ = ethanol + NADP+
show the reaction diagram
-
acetaldehyde + NADH + H+ = ethanol + NAD+
show the reaction diagram
-
acetaldehyde + NADPH + H+ = ethanol + NADP+
show the reaction diagram
-
acetaldehyde + NADPH + H+ = ethanol + NADP+
show the reaction diagram
-
acetaldehyde + NADPH + H+ = ethanol + NADP+
show the reaction diagram
-
acetaldehyde + NAD+ = ethanol + NADH + H+
show the reaction diagram
-
acetaldehyde + 2 reduced cytochrome cL = ethanol + 2 oxidizeded cytochrome cL
show the reaction diagram
-
acetaldehyde + phenazine methosulfate = ? + reduced phenazine methosulfate
show the reaction diagram
-
acetaldehyde + ferricytochrome c = ?
show the reaction diagram
-
acetaldehyde + acceptor + H2O = acetic acid + reduced acceptor
show the reaction diagram
-
acetaldehyde + H2O + O2 = acetic acid + H2O2
show the reaction diagram
-
acetaldehyde + benzaldehyde = (R)-phenylacetylcarbinol
show the reaction diagram
-
acetaldehyde + phosphate + NAD+ = acetyl phosphate + NADH
show the reaction diagram
acetaldehyde + NADP+ + H2O = succinate + NADPH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD(P)+ + H2O = acetate + NAD(P)H + H+
show the reaction diagram
-
acetaldehyde + CoA + NAD+ = ?
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + 2 H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + NAD+ + H2O = acetate + NADH + H+
show the reaction diagram
-
acetaldehyde + phosphate + O2 + H2O = ? + H2O2
show the reaction diagram
-
acetaldehyde + O2 + H2O = acetate + H2O2
show the reaction diagram
-
acetaldehyde + benzaldehyde = (R)-phenylacetylcarbinol
show the reaction diagram
-
acetaldehyde + 2,6-dichlorophenolindophenol + H2O = acetate + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
acetaldehyde + D-xylulose 5-phosphate = glyceraldehyde 3-phosphate + 1,3-dihydroxybutane-2-one
show the reaction diagram
-
2-oxoglutarate + acetaldehyde = 5-hydroxy-4-oxohexanoate + CO2
show the reaction diagram
-
acetaldehyde + 2-oxoglutarate = (5R)-5-hydroxy-4-oxohexanoic acid + CO2
show the reaction diagram
-
taurine + ethanal = 2-sulfoacetaldehyde + ethylamine
show the reaction diagram
-
pyruvate oxime + acetaldehyde = pyruvate + acetaldoxime
show the reaction diagram
-
4-nitrocyclohexan-1-one + acetaldehyde = ?
show the reaction diagram
-
2 acetaldehyde = 5-deoxy-D-threo-2-pentulose
show the reaction diagram
Glycerone phosphate + acetaldehyde = 5-Deoxy-L-xylulose 1-phosphate
show the reaction diagram
-
formate + acetaldehyde = lactate
show the reaction diagram
-
D-ribulose 5-phosphate + acetaldehyde = ?
show the reaction diagram
-
glycine + acetaldehyde = L-threonine
show the reaction diagram
-
glycine + acetaldehyde = L-allo-threonine
show the reaction diagram
-
glycine + acetaldehyde = L-threonine
show the reaction diagram
-
acetaldehyde + glyoxylate = ?
show the reaction diagram
-
acetaldehyde + NH3 = ethanolamine
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (220 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ethanol + NAD+ = acetaldehyde + NADH + H+
show the reaction diagram
-
ethanol + NAD+ = acetaldehyde + NADH + H+
show the reaction diagram
-
ethanol + NAD+ = acetaldehyde + NADH
show the reaction diagram
-
ethanol + NAD+ = acetaldehyde + NADH
show the reaction diagram
-
ethanol + NAD+ + H2O = ethanal + NADH
show the reaction diagram
-
ethanol + NADP+ = acetaldehyde + NADPH + H+
show the reaction diagram
-
ethanol + NAD+ = acetaldehyde + NADH
show the reaction diagram
-
ethanol + NAD+ = ethanal + NADH + H+
show the reaction diagram
-
ethanol + NADP+ = ethanal + NADPH + H+
show the reaction diagram
-
ethanol + NAD+ = acetaldehyde + NADH
show the reaction diagram
-
ethanol + NADP+ = acetaldehyde + NADPH + H+
show the reaction diagram
-
ethanol + NAD+ = ethanal + NADH
show the reaction diagram
-
ethanol + ferricytochrome c = acetaldehyde + ferrocytochrome c + H+
show the reaction diagram
-
ethanol + N,N,N',N'-tetramethyl-4-phenylenediamine = acetaldehyde + reduced N,N,N',N'-tetramethyl-4-phenylenediamine
show the reaction diagram
-
ethanol + O2 = acetaldehyde + H2O2
show the reaction diagram
-
ethanol + O2 = ethanal + H2O2
show the reaction diagram
-
ethanol + O2 = acetaldehyde + H2O2
show the reaction diagram
-
ethanol + a quinone = acetaldehyde + a quinol
show the reaction diagram
-
ethanol + phenazine methosulfate = acetaldehyde + reduced phenazine methosulfate
show the reaction diagram
-
ethanol + acceptor = ethanal + reduced acceptor
show the reaction diagram
-
ethanol + acceptor = acetaldehyde + reduced acceptor
show the reaction diagram
-
ethanol + N,N-dimethyl-4-nitrosoaniline = acetaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
show the reaction diagram
-
ethanol + N,N-dimethyl-4-nitrosoaniline = acetaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
show the reaction diagram
-
ethanol + H2O2 = acetaldehyde + ?
show the reaction diagram
-
isoeugenol + O2 = vanillin + acetaldehyde
show the reaction diagram
-
diethyl sulfide + O2 + NADH = ethanethiol + acetaldehyde + NAD+ + H2O
show the reaction diagram
-
diethyl ether + NAD(P)H + O2 = ethanol + ethanal + NAD(P)+ + H2O
show the reaction diagram
-
17alpha-Hydroxypregnenolone = Dehydroepiandrosterone + acetaldehyde
show the reaction diagram
-
ethanesulfonate + FMNH2 + O2 = acetaldehyde + FMN + sulfite + H2O
show the reaction diagram
-
ethyl tert-butyl ether + NAD(P)H + H+ + O2 = tert-butyl-alcohol + NAD(P)+ + H2O + acetaldehyde
show the reaction diagram
-
ethane + duroquinol + O2 = ethanal + duroquinone + H2O
show the reaction diagram
-
4-ethoxybenzoate + NADH + O2 = 4-hydroxybenzoate + acetaldehyde + NAD+ + H2O
show the reaction diagram
-
(1E)-2-methyl-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-1-en-1-yl acetate + O2 = 4-(2,6,6-trimethylcyclohex-1-en-1-yl)butan-2-one + CO2 + acetaldehyde
show the reaction diagram
-
acetate + NADH + H+ = acetaldehyde + NAD+ + H2O
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
pyruvate + oxidized 2,6-dichlorophenolindophenol = acetaldehyde + CO2 + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
ethanol + p-nitroso-N,N-dimethylaniline = ethanal + reduced p-nitroso-N,N-dimethylaniline
show the reaction diagram
-
ethylamine + NAD+ + H2O = acetaldehyde + NH3 + NADH + H+
show the reaction diagram
-
ethylamine + H2O + O2 = acetaldehyde + NH3 + H2O2
show the reaction diagram
-
ethylamine + H2O + O2 = ethanal + NH3 + H2O2
show the reaction diagram
-
ethylamine + acceptor + H2O = acetaldehyde + NH3 + reduced acceptor
show the reaction diagram
-
fructosyl glycine lysine + O2 + H2O = (1-deoxy-D-fructos-1-yl)amine + acetaldehyde + H2O2
show the reaction diagram
-
N6-ethyl-L-lysine + H2O + O2 = L-lysine + acetaldehyde + H2O2
show the reaction diagram
-
diethylamine + H2O + acceptor = ethylamine + acetaldehyde + reduced acceptor
show the reaction diagram
-
ethyl mercaptan + O2 + H2O = acetaldehyde + H2S + H2O2
show the reaction diagram
-
3-hydroxybutan-2-one + D-ribose 5-phosphate = acetaldehyde + 1-deoxy-D-altro-heptulose 7-phosphate
show the reaction diagram
-
4-aminobutyrate + 2-oxoglutarate = L-glutamate + acetaldehyde + sulfite
show the reaction diagram
-
pyruvate = acetaldehyde + CO2
show the reaction diagram
-
pyruvate = acetaldehyde + CO2
show the reaction diagram
-
(24R,241R)-fucosterol epoxide = desmosterol + acetaldehyde
show the reaction diagram
-
2-oxo-3-methyl-4-hydroxypentanoate = 2-oxobutyrate + acetaldehyde
show the reaction diagram
-
DL-Allothreonine = Acetaldehyde + Gly
show the reaction diagram
-
acetylene + H2O = acetaldehyde
show the reaction diagram
-
3-(methylthio)acryloyl-CoA + 2 H2O = acetaldehyde + methanethiol + CoA + CO2
show the reaction diagram
-
ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate
show the reaction diagram
-
ethanolamine = acetaldehyde + NH3
show the reaction diagram
-
choline = trimethylamine + acetaldehyde
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate activation at elevated aldehyde concentrations
-
activates
-
the enzyme shows the highest activity at up to 100 mM acetaldehyde, and also shows some activity at 300 mM acetaldehyde
-

Inhibitor in Enzyme-catalyzed Reactions (120 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 40% inhibition; 40% inhibition at 1 mM, 60% at 2 mM, and 95% at 10 mM
-
inactivation
-
competitive inhibition
-
weak
-
2-oxoglutarate dehydrogenase complex
-
strongly inhibits 4-aminobutyraldehyde oxidation
-
about 10% inhibition at 3 mM
-
substrate n-butanol
-
1 mM causes 18% inhibition at 30°C
-
strong substrate inhibition
-
0.2 mM, 34.6% inhibition
-
77% inhibition at 5 mM, partially reversed by retinal
-
50% inhibition at 5 mM
-
5 mM, 50% inhibition
-
about 50% inhibition at 20 mM
-
noncompetitive inhibition with respect to diethylamine, uncompetitive inhibition with respect to phenazine methosulfate
-
noncompetitive inhibitor versus nitroethane due to formation of a dead-end complex between the oxidized enzyme and the product, competitive inhibitor versus oxygen
-
above 0.01 M, microsomal enzyme, above 0.2 M, solubilized peroxisomal enzyme
-
weak
-
about 3% activity at 2 mM
-
the enzymic cleavage of L-threonine stops when about 30% of the amino acid is converted to glycine and acetaldehyde. By dialysis of the incubation medium against buffer the full activity of the enzyme is restored, product inhibition
-
Ki: 11 mM
-

3D Structure of Enzyme-Ligand-Complex (PDB) (2544 results)

EC NUMBER
ENZYME 3D STRUCTURE