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Ligand coproporphyrin III Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C3 6 H3 8 N4 O8
coproporphyrin III
WVVBSKRXVLOOFW-UJJXFSCMSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
coproporphyrin III + Fe2+ = Fe-coproporphyrin III + 2 H+
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2
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coproporphyrinogen III + O2 = coproporphyrin III + H2O
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coproporphyrinogen III + O2 = coproporphyrin III + H2O
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Substrate in Enzyme-catalyzed Reactions (5 results)
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coproporphyrin III + 2 S-adenosyl-L-methionine = ? + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine
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coproporphyrin III + Co2+ = Co-coproporphyrin III + 2 H+
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coproporphyrin III + Cu2+ = Cu-coproporphyrin III + 2 H+
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coproporphyrin III + Fe2+ = Fe-coproporphyrin III + 2 H+
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coproporphyrin III + Ni2+ = Ni-coproporphyrin III + 2 H+
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Product in Enzyme-catalyzed Reactions (4 results)
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coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2
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coproporphyrinogen III + O2 = coproporphyrin III + H2O
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coproporphyrinogen III + O2 = coproporphyrin III + H2O
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coproporphyrinogen-III + 3 O2 = coproporphyrin-III + 3 H2O2
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Inhibitor in Enzyme-catalyzed Reactions (3 results)
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52% inhibition at 0.0194 mM
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (2 results)
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KM Value (2 results)
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References & Links Literature References (5)
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Purification and properties of the uroporphyrinogen decarboxylase from Rhodobacter sphaeroides
1993
Jones, R.M.; Jordan, P.M.
Biochem. J.
293
703-712
A radiochemical method for the measurement of coproporphyrinogen oxidase and the utilization of substrates other than coproporphyrinogen III by the enzyme from rat liver
1978
Elder, G.H.; Evans, J.O.
Biochem. J.
169
205-214
Purification and properties of coproporphyrinogen III oxidase from yeast
1997
Labbe, P.
Methods Enzymol.
281
367-378
Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin
2015
Dailey, H.A.; Gerdes, S.; Dailey, T.A.; Burch, J.S.; Phillips, J.D.
Proc. Natl. Acad. Sci. USA
112
2210-2215
The auxiliary [4Fe-4S] cluster of the radical SAM heme synthase from Methanosarcina barkeri is involved in electron transfer
2016
Kuehner, M.; Schweyen, P.; Hoffmann, M.; Ramos, J.; Reijerse, E.; Lubitz, W.; Broering, M.; Layer, G.
Chem. Sci.
7
4633-4643
Links to other databases for coproporphyrin III
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