Ligand a carboxylate

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Basic Ligand Information

Molecular Structure
Picture of a carboxylate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H7O2R
a carboxylate
QAZUTYIRTMVIBB-UHFFFAOYSA-N
Synonyms:
a carboxylic acid, a carboxylic acid anion, acylic acid, alkanate, an acid, carboxylate, carboxylates, carboxylic acid, carboxylic acid anion, carboxylic acids, n-alkanoic acid, R-COOH, RCOOH

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carboxylic acid + hydroxylamine = N-hydroxy-carboxylic acid amide + H2O
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (46 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carboxylic aldehyde + H2O + O2 = carboxylic acid + H2O2
show the reaction diagram
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an aldehyde + NAD+ + H2O = an acid + NADH + H+
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an aldehyde + NADP+ + H2O = an acid + NADPH + H+
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an aldehyde + H2O + oxidized ferredoxin = an acid + H+ + reduced ferredoxin
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acyl phosphate + D-hexose = an acid + D-hexose phosphate
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triacylglycerol + H2O = diacylglycerol + a carboxylate
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triacylglycerol + H2O = diacylglycerol + a carboxylate
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phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
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acyl-CoA + H2O = CoA + a carboxylate
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acyl-CoA + H2O = CoA + a carboxylate
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acyl-CoA + H2O = CoA + a carboxylate
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N-acetyl-L-amino acid + H2O = carboxylic acid + L-amino acid
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N-acyl-D-amino acid + H2O = a carboxylate + D-amino acid
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N-acyl-(S)-homoserine lactone + H2O = (S)-homoserine lactone + carboxylic acid
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5'-acylphosphoadenosine + H2O = AMP + carboxylate
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acylphosphate + H2O = a carboxylate + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
R-COOH + ATP = R-CO-AMP + diphosphate
show the reaction diagram
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carboxylic acid + hydroxylamine = N-hydroxy-carboxylic acid amide + H2O
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Product in Enzyme-catalyzed Reactions (89 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
aliphatic aldehyde + acceptor + H2O = carboxylic acid + reduced acceptor
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carboxylic aldehyde + H2O + O2 = carboxylic acid + H2O2
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aldehydes + NAD+ + H2O = carboxylic acids + NADH
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an aldehyde + NAD+ + H2O = an acid + NADH + H+
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an aldehyde + NADP+ + H2O = an acid + NADPH + H+
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n-alkanal + H2O + O2 = n-alkanoic acid + H2O2
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an aldehyde + H2O + oxidized ferredoxin = an acid + H+ + reduced ferredoxin
show the reaction diagram
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aldehyde + H2O + acceptor = carboxylate + reduced acceptor
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acyl phosphate + D-hexose = an acid + D-hexose phosphate
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1-chloro-3-(1-naphthyloxy)-2-propanol acylester + H2O = (R)-1-chloro-3-(1-naphthyloxy)-2-propanol + carboxylic acid
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triacylglycerol + H2O = diacylglycerol + carboxylic acid
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triacylglycerol + H2O = diacylglycerol + a carboxylate
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1-acyl-2-linoleoyl-glycero-phosphocholine + H2O = 2-linoleoyl-glycero-phosphocholine + acylic acid
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4-nitrophenyl acylester + H2O = 4-nitrophenol + carboxylic acid
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acyl-CoA + H2O = CoA + a carboxylate
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penicillin + H2O = a carboxylate + 6-aminopenicillanate
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aliphatic carboxylic acid amides + H2O = carboxylic acid + NH3
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N-acyl-D-amino acid + H2O = a carboxylate + D-amino acid
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N-acyl-(S)-homoserine lactone + H2O = (S)-homoserine lactone + carboxylic acid
show the reaction diagram
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R-CN + H2O = R-COOH + NH3
show the reaction diagram
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5'-acylphosphoadenosine + H2O = AMP + carboxylate
show the reaction diagram
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polyvinyl alcohol + H2O = carboxylic acid + methyl ketone
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates, stimulation is non-competitive, hyperbolic and its dimension is directly related to the number of carboxylic groups on the activator. Stimulation does not affect the yield of oxidative phosphorylation
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive for acetic and propionic acid, mixed-type from pentanoic to undecanoic acid with exception of heptanoic acid
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structural characterization of enzyme-inhibitor interaction
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Enzyme Kinetic Parameters

References & Links

Links to other databases for a carboxylate

ChEBI
PubChem
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PubChem