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Ligand dTDP-alpha-D-fucopyranose

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for dTDP-alpha-D-fucopyranose

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.266

dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-D-glucose + NADPH

246376

-

1.1.1.B28

dTDP-alpha-D-fucopyranose + NADP+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADPH + H+

723209

-

5.4.99.59

dTDP-alpha-D-fucopyranose = dTDP-beta-D-fuco-(1->4)-furanose

723209

-

Substrate in Enzyme-catalyzed Reactions (6 results)

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Show Substrate (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.266

dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-D-glucose + NADPH

246376

-

1.1.1.B28

dTDP-alpha-D-fucopyranose + NADH + H+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NAD+

723209

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1.1.1.B28

dTDP-alpha-D-fucopyranose + NADP+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADPH + H+

723209

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1.1.1.B28

dTDP-alpha-D-fucopyranose + NADPH + H+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADP+

723209

-

1.1.1.B28

3 entries

5.1.3.2

TDP-6-deoxy-D-galactose = ?

2320

-

5.4.99.59

dTDP-alpha-D-fucopyranose = dTDP-beta-D-fuco-(1->4)-furanose

723209

-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

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Show Inhibitors (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.46

-

5714

-

4.2.1.46

competitive inhibitor

5716

-

4.2.1.46

2 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

5.4.99.59

0.056

-

pH 7.4, 37°C

723209

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

5.4.99.59

3.43

-

pH 7.4, 37°C

723209

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

2320

-

UDP-galactose-4-epimerase

1975

Gabrial, O.; Kalckar, H.M.; Darrow, R.A.

ubunit enzymes: biochemistry and function (Ebner, K. B., ed.)

2

85-135

5714

-

Dehydration in nucleotide-linked deoxysugar synthesis

1971

Glaser, L.; Zarkowsky, H.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

5

465-480

5716

4315353

The mechanism of 6-deoxyhexose synthesis. IV. The role of pyridine nucleotide in substrate release

1970

Zarkowsky, H.; Lipkin, E.; Glaser, L.

Biochem. Biophys. Res. Commun.

38

787-793

246376

10358040

A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the synthesis of thymidine diphosphate-D-fucose

1999

Yoshida, Y.; Nakano, Y.; Nezu, T.; Yamashita, Y.; Koga, T.

J. Biol. Chem.

274

16933-16939

723209

19019146

Characterization of the dTDP-D-fucofuranose biosynthetic pathway in Escherichia coli O52

2008

Wang, Q.; Ding, P.; Perepelov, A.V.; Xu, Y.; Wang, Y.; Knirel, Y.A.; Wang, L.; Feng, L.

Mol. Microbiol.

70

1358-1367

Links to other databases for dTDP-alpha-D-fucopyranose

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Show Links (1 entry)