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BRENDA support

Ligand antimycin A

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Basic Ligand Information

Molecular Structure
Picture of antimycin A (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C28H40N2O9
antimycin A
UIFFUZWRFRDZJC-SBOOETFBSA-N
Synonyms:
antimycin-A, Antimycin 1

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
-

Inhibitor in Enzyme-catalyzed Reactions (38 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
12% inhibition at 1 mM
-
inhibits electron transfer from quinone to cytochrome c
-
3% inhibition at 1 mM
-
inhibits electron transfer from quinone to cytochrome c
-
56% residual activity at 0.005 mg/ml; 56% residual activity at 0.005 mg/ml
-
0.1 mM, 47% inhibition
-
18% inhibition at 0.02 mM
-
15% inhibition at 1mg per l
-
0.1 mM, 44% inhibition
-
0.005 mM, 16% loss of activity
-
10 microM, 45.6% residual AtraAOX2 activity
-
site of inhibition is located at the oxidation side of cytochrome b
-
0.05 mM, 50% inhibition
-
very strong inhibition
-
0.1 mM, 26% inhibition of hydroxylamine reductase activity
-
0.2 mM, 45% inhibition
-
100% inhibition at 0.0075 mg per ml, no inhibition with ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors
-
55% inhibition at 0.027 mM
-
inhibits groth on iodate and iodate reduction completely
-
0.0009 mM
-
more than 10fold less effective than 2-(n-heptyl)-4-hydroxyquinoline-N-oxide, 39% residual activity at 0.01 mM
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

IC50 Value (6 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.017
-
at 25°C in 50 mM potassium phosphate (pH 6.5)
0.00004
-
-

References & Links

Links to other databases for antimycin A

ChEBI
PubChem
ChEBI
PubChem