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Literature summary for 1.1.1.1 extracted from

  • Bosron, W.F.; Li, T.K.; Dafeldecker, W.P.; Vallee, B.L.
    Human liver pig-alcohol dehydrogenase: kinetic and molecular properties (1979), Biochemistry, 18, 1101-1105.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-bromopyrazole
-
Homo sapiens
4-cyanopyrazole
-
Homo sapiens
4-iodopyrazole
-
Homo sapiens
4-methoxypyrazole 1 mM, 28% inhibition Homo sapiens
4-Methylpyrazole 1 mM, 31% inhibition Homo sapiens
4-nitropyrazole
-
Homo sapiens
4-pentylpyrazole
-
Homo sapiens
4-propylpyrazole
-
Homo sapiens
pyrazole no inhibition at 1.0 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc contains 3.7 gatom of zinc per mol of enzyme Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
2 * 40000, SDS-PAGE Homo sapiens
78000
-
ultracentrifugation under non-denaturing conditions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoenzyme pi
-

Reaction

Reaction Comment Organism Reaction ID
a primary alcohol + NAD+ = an aldehyde + NADH + H+ ordered bi bi mechanism with cofactor adding first to form a binary enzyme complex Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Storage Stability

Storage Stability Organism
4°C, 5 mM Na-phosphate, pH 7.5, 50% loss of activity after 1 day. Enzyme can be stabilized for up to 2 weeks by storage in buffer containing 10 mM ethanol Homo sapiens

Subunits

Subunits Comment Organism
dimer 2 * 40000, SDS-PAGE Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADH
-
Homo sapiens