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Literature summary for 1.1.1.1 extracted from

  • Barzegar, A.; Moosavi-Movahedi, A.; Pedersen, J.; Miroliaei, M.
    Comparative thermostability of mesophilic and thermophilic alcohol dehydrogenases: Stability-determining roles of proline residues and loop conformations (2009), Enzyme Microb. Technol., 45, 73-79.
No PubMed abstract available
Search for more literature for 1.1.1.1

Organism

Organism UniProt Comment Textmining
Equus caballus P00327
-
-
Saccharomyces cerevisiae P00330
-
-
Thermoanaerobacter brockii
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyl alcohol + NAD+
-
 Thermoanaerobacter brockii benzaldehyde + NADH + H+
-
 ?
benzyl alcohol + NAD+
-
 Saccharomyces cerevisiae benzaldehyde + NADH + H+
-
 ?
benzyl alcohol + NAD+
-
 Equus caballus benzaldehyde + NADH + H+
-
 ?
ethanol + NAD+
-
 Thermoanaerobacter brockii acetaldehyde + NADH + H+
-
 ?
ethanol + NAD+
-
 Saccharomyces cerevisiae acetaldehyde + NADH + H+
-
 ?
ethanol + NAD+
-
 Equus caballus acetaldehyde + NADH + H+
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Equus caballus
tetramer
-
 Thermoanaerobacter brockii
tetramer
-
 Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
ADH
-
 Thermoanaerobacter brockii
ADH
-
 Saccharomyces cerevisiae
ADH
-
 Equus caballus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 approximately 30°C Saccharomyces cerevisiae
70
-
 approximately 70°C Equus caballus
85
-
 approximately 85°C Thermoanaerobacter brockii

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
30 55 the specific activity of ADH decreases rapidly above 30°C, ADH is almost completely inactive after a 36 min incubation at 55°C Saccharomyces cerevisiae
55
-
 ADH is insensitive to thermal stress at 55°C and remains fully active after a 36 min incubation at 55°C Thermoanaerobacter brockii
55
-
 ADH loses less than 30% of its initial activity after a 36 min incubation at 55°C Equus caballus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Thermoanaerobacter brockii
NAD+
-
 Saccharomyces cerevisiae
NAD+
-
 Equus caballus