Literature summary for 1.1.1.138 extracted from

Schneider, P.B.; Denk, U.; Breitenbach, M.; Richter, K.; Schmid-Grendelmeier, P.; Nobbe, S.; Himly, M.; Mari, A.; Ebner, C.; Simon-Nobbe, B.
Alternaria alternata NADP-dependent mannitol dehydrogenase is an important fungal allergen (2006), Clin. Exp. Allergy, 36, 1513-1524.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Alternaria alternata

Inhibitors

Inhibitors	Comment	Organism	Structure
D-fructose	substrate inhibition occurred at concentrations above 750 mM	Alternaria alternata

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0187	-	NADPH	+/- 0.0035 mM, pH 7.0, room temperature	Alternaria alternata
0.0187	-	NADPH	plusminus 0.0035 mM, pH 7.0, room temperature	Alternaria alternata
474	-	D-fructose	+/- 80 mM, pH 7.0, room temperature	Alternaria alternata
474	-	D-fructose	plusminus 80 mM, pH 7.0, room temperature	Alternaria alternata

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
28610	-	-	Alternaria alternata

Organism

Organism	UniProt	Comment	Textmining
Alternaria alternata	P0C0Y4	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-fructose + NADPH + H+	-	Alternaria alternata	D-mannitol + NADP+	-	r

Synonyms

Synonyms	Comment	Organism
MtDH	-	Alternaria alternata
NADP-dependent mannitol dehydrogenase	-	Alternaria alternata

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Alternaria alternata
NADPH	-	Alternaria alternata

pI Value

Organism	Comment	pI Value Maximum	pI Value
Alternaria alternata	-	-	5.88

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Release 2023.1 (January 2023)