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Literature summary for 1.1.1.141 extracted from

  • Backlund, M.G.; Mann, J.R.; Holla, V.R.; Buchanan, F.G.; Tai, H.H.; Musiek, E.S.; Milne, G.L.; Katkuri, S.; DuBois, R.N.
    15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer (2005), J. Biol. Chem., 280, 3217-3223.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.141

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme expression is inducible by indomethacin in LS174T cells, but not in HCA-7 and HCT-15 cells, and also not in enzyme-deficient HCT-116 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Mus musculus PGE2 degradation (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens PGE2 degradation (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene 15-Pgdh
-
Mus musculus
-
 gene 15-Pgdh
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder
-
 Homo sapiens
-
colorectal cancer cell the enzyme expression is down-regulated Homo sapiens
-
DLD-1 cell low enzyme expression level Homo sapiens
-
embryo low enzyme expression level Mus musculus
-
HCA-7 cell low enzyme expression level Homo sapiens
-
HCT-15 cell
-
 Homo sapiens
-
HT-29 cell very low enzyme expression level Homo sapiens
-
kidney very low expression level Homo sapiens
-
kidney low enzyme expression level Mus musculus
-
liver
-
 Homo sapiens
-
liver high enzyme expression level Mus musculus
-
LoVo cell
-
 Homo sapiens
-
LS174T cell very low enzyme expression level Homo sapiens
-
lung
-
 Homo sapiens
-
lung high enzyme expression level Mus musculus
-
additional information distribution of enzyme expression in normal and pathological tissues, overview, no enzyme expression in spleen, heart, HCT-116 cells, CacO-2 cells and Colo 201 cells Homo sapiens
-
additional information tissue distribution of enzyme expression, overview, no expression in heart and brain Mus musculus
-
ovary low enzyme expression level Mus musculus
-
prostate gland very low expression level Homo sapiens
-
small intestine
-
 Homo sapiens
-
spleen low enzyme expression level Mus musculus
-
SW-480 cell very low enzyme expression level Homo sapiens
-
testis very low enzyme expression level Mus musculus
-
thymus low enzyme expression level Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ PGE2 degradation Mus musculus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ PGE2 degradation Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or PGE2 Mus musculus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or PGE2 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
15-hydroxyprostaglandin dehydrogenase
-
 Mus musculus
15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens
15-PGDH
-
 Mus musculus
15-PGDH
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mus musculus
NAD+
-
 Homo sapiens