Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | Homo sapiens | - |
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15428 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CCD-841 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | - |
Homo sapiens | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-PGDH | - |
Homo sapiens |
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is a tumor suppressor in various malignancies including colon cancer. The product (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate (15-keto PGE2) stimulates the Nrf2-HO-1 axis through the generation of ROS in normal colon epithelial cells, which contributes to the potential role of this lipid mediator in preventing cancer development associated with oxidative stress and inflammatory tissue damage | Homo sapiens |