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Literature summary for 1.1.1.145 extracted from

  • Louw-du Toit, R.; Perkins, M.S.; Snoep, J.L.; Storbeck, K.H.; Africander, D.
    Fourth-generation progestins inhibit 3beta-hydroxysteroid dehydrogenase type 2 and modulate the biosynthesis of endogenous steroids (2016), PLoS ONE, 11, e0164170.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
drospirenone
-
Homo sapiens
nestorone
-
Homo sapiens
nomegestrol acetate
-
Homo sapiens
trilostane
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17alpha-hydroxypregnenolone + NAD+ Homo sapiens
-
17alpha-hydroxy-pregn-5-en-3,20-dione + NADH
-
?
dehydroepiandrosterone + NAD+ Homo sapiens
-
androst-5-en-3,17-dione + NADH + H+
-
?
pregnenolone + NAD+ Homo sapiens
-
pregn-5-en-3,20-dione + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenocortical carcinoma cell
-
Homo sapiens
-
H-295R cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-hydroxypregnenolone + NAD+
-
Homo sapiens 17alpha-hydroxy-pregn-5-en-3,20-dione + NADH
-
?
dehydroepiandrosterone + NAD+
-
Homo sapiens androst-5-en-3,17-dione + NADH + H+
-
?
pregnenolone + NAD+
-
Homo sapiens pregn-5-en-3,20-dione + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
3beta-hydroxysteroid dehydrogenase type 2 and
-
Homo sapiens
3betaHSD2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000095
-
nestorone pH and temperature not specified in the publication Homo sapiens
0.000029
-
nomegestrol acetate pH and temperature not specified in the publication Homo sapiens
0.000031
-
trilostane pH and temperature not specified in the publication Homo sapiens
0.000232
-
drospirenone pH and temperature not specified in the publication Homo sapiens