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Literature summary for 1.1.1.145 extracted from

  • Ando, T.; Nishiyama, T.; Takizawa, I.; Ishizaki, F.; Miyashiro, Y.; Takeda, K.; Hara, N.; Tomita, Y.
    Dihydrotestosterone synthesis pathways from inactive androgen 5alpha-androstane-3beta,17beta-diol in prostate cancer cells: Inhibition of intratumoural 3beta-hydroxysteroid dehydrogenase activities by abiraterone (2016), Sci. Rep., 6, 32198.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.145

Inhibitors

Inhibitors Comment Organism Structure
abiraterone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dehydroepiandrosterone + NAD+ Homo sapiens
-
 androst-5-en-3,17-dione + NADH + H+
-
 ?
DELTA5-androstenediol + NAD+ Homo sapiens
-
 testosterone + NADH + H+
-
 ?
epiandrosterone + NAD+ Homo sapiens
-
 5alpha-androstan-3,17-dione + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-
VCaP cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone + NAD+
-
 Homo sapiens androst-5-en-3,17-dione + NADH + H+
-
 ?
DELTA5-androstenediol + NAD+
-
 Homo sapiens testosterone + NADH + H+
-
 ?
epiandrosterone + NAD+
-
 Homo sapiens 5alpha-androstan-3,17-dione + NADH + H+
-
 r

Synonyms

Synonyms Comment Organism
3beta-HSD
-
 Homo sapiens
3beta-hydroxysteroid dehydrogenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism isoform 3bHSD2 interacts with the mitochondrial translocase, Tim50, to regulate progesterone and androstenedione formation Homo sapiens