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Literature summary for 1.1.1.146 extracted from

  • Monder, C.; Lakshmi, V.
    Evidence for kinetically distinct forms of corticosteroid 11beta-dehydrogenase in rat liver microsomes (1989), J. Steroid Biochem., 32, 77-83.
    View publication on PubMed
Search for more literature for 1.1.1.146

Inhibitors

Inhibitors Comment Organism Structure
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione i.e. cortisol; poor inhibition of corticosterone oxidation Rattus sp.
11beta,21-dihydroxypregn-4-en-3,20-dione potent inhibition of cortisol oxidation Rattus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information high- and low Km forms, suggesting 2 isoenzymes, high-Km form represents 90% of total activity in untreated microsomes Rattus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ Rattus sp. i.e. cortisol 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH i.e. cortisone ?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ Rattus sp. 10-20fold faster than cortisol oxidation 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
 ?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH Rattus sp. i.e. cortisone 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol Rattus sp. 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH i.e. cortisone ?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ 10-20fold faster than cortisol oxidation Rattus sp. 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
 ?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH i.e. cortisone Rattus sp. 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5 9.5 stimulated enzyme preparation Rattus sp.
10
-
 latent, detergent-treated preparation Rattus sp.