Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arylsulfoamidothiazole | - |
Cavia porcellus | |
arylsulfoamidothiazole | - |
Homo sapiens | |
arylsulfoamidothiazole | - |
Rattus norvegicus | |
arylsulfoamidothiazoles | weak or not binding inhibitors, inhibition mode and profiles | Cavia porcellus | |
arylsulfoamidothiazoles | specific, tight-binding inhibitors, inhibition mode and profiles | Homo sapiens | |
arylsulfoamidothiazoles | intermediate binding inhibitors, inhibition mode and profiles | Mus musculus | |
arylsulfoamidothiazoles | weak or not binding binding inhibitors, inhibition mode and profiles | Rattus norvegicus | |
BVT-2733 | mixed-type inhibition pattern | Mus musculus | |
BVT-528 | competitive, tight-binding inhibition pattern | Homo sapiens | |
carbenoxolone | unspecific inhibitor | Cavia porcellus | |
carbenoxolone | unspecific inhibitor | Homo sapiens | |
carbenoxolone | unspecific inhibitor | Mus musculus | |
carbenoxolone | unspecific inhibitor | Rattus norvegicus | |
additional information | structure-activity analysis for inhibitor design | Cavia porcellus | |
additional information | structure-activity analysis for inhibitor design | Homo sapiens | |
additional information | structure-activity analysis for inhibitor design | Mus musculus | |
additional information | structure-activity analysis for inhibitor design | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | isozyme 11beta-HSD1 is anchored through an N-terminal transmembrane domain | Cavia porcellus | 5789 | - |
endoplasmic reticulum membrane | isozyme 11beta-HSD1 is anchored through an N-terminal transmembrane domain | Mus musculus | 5789 | - |
endoplasmic reticulum membrane | isozyme 11beta-HSD1 is anchored through an N-terminal transmembrane domain | Rattus norvegicus | 5789 | - |
endoplasmic reticulum membrane | isozyme 11beta-HSD1 is anchored through an N-terminal transmembrane domain | Homo sapiens | 5789 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | Homo sapiens | isozyme 11beta-HSD1 | cortisol + NADP+ | - |
? | |
additional information | Cavia porcellus | the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner | ? | - |
? | |
additional information | Mus musculus | the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner | ? | - |
? | |
additional information | Rattus norvegicus | the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner | ? | - |
? | |
additional information | Homo sapiens | the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
isozyme 11beta-HSD1 | - |
Homo sapiens | P28845 | isozyme 11beta-HSD1 | - |
Mus musculus | - |
isozyme 11beta-HSD1 | - |
Rattus norvegicus | - |
isozyme 11beta-HSD1 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ | active site variability of isozyme 11beta-HSD1, structure-activity analysis, catalytic mechanism | Cavia porcellus | |
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ | active site variability of isozyme 11beta-HSD1, structure-activity analysis, catalytic mechanism | Mus musculus | |
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ | active site variability of isozyme 11beta-HSD1, structure-activity analysis, catalytic mechanism | Rattus norvegicus | |
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ | active site variability of isozyme 11beta-HSD1, structure-activity analysis, catalytic mechanism | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | isozyme 11beta-HSD1 | Homo sapiens | cortisol + NADP+ | - |
? | |
additional information | the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner | Cavia porcellus | ? | - |
? | |
additional information | the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner | Mus musculus | ? | - |
? | |
additional information | the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner | Rattus norvegicus | ? | - |
? | |
additional information | the enzyme activates pro-glucocorticoid hormones in a tissue-specific manner | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | comparison of primary structures, three-dimensional structure around the substrate binding site, and active site amino acid sequences of several mammalia | Cavia porcellus |
More | comparison of primary structures, three-dimensional structure around the substrate binding site, and active site amino acid sequences of several mammalia | Mus musculus |
More | comparison of primary structures, three-dimensional structure around the substrate binding site, and active site amino acid sequences of several mammalia | Rattus norvegicus |
More | comparison of primary structures, three-dimensional structure around the substrate binding site, and active site amino acid sequences of several mammalia | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Cavia porcellus |
11beta-HSD1 | - |
Mus musculus |
11beta-HSD1 | - |
Rattus norvegicus |
11beta-HSD1 | - |
Homo sapiens |
More | the enzyme belongs to the short-chain dehydrogenase/reductase superfamily | Cavia porcellus |
More | the enzyme belongs to the short-chain dehydrogenase/reductase superfamily | Mus musculus |
More | the enzyme belongs to the short-chain dehydrogenase/reductase superfamily | Rattus norvegicus |
More | the enzyme belongs to the short-chain dehydrogenase/reductase superfamily | Homo sapiens |
type 1 11beta-hydroxysteroid dehydrogenase | - |
Cavia porcellus |
type 1 11beta-hydroxysteroid dehydrogenase | - |
Mus musculus |
type 1 11beta-hydroxysteroid dehydrogenase | - |
Rattus norvegicus |
type 1 11beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Cavia porcellus | |
NADPH | - |
Mus musculus | |
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00005 | - |
arylsulfoamidothiazole | - |
Homo sapiens | |
0.003 | - |
arylsulfoamidothiazole | above | Cavia porcellus | |
0.003 | - |
arylsulfoamidothiazole | above | Rattus norvegicus |