KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000102 | - |
NAD+ | isoform 11beta-HSD2, kidney homogenate | Homo sapiens | |
0.00042 | - |
NADP+ | isoform 11beta-HSD1, kidney homogenate | Homo sapiens | |
0.00042 | - |
NADP+ | kidney homogenate, pH and temperature not specified in the publication | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | similar amounts of protein for both isoform 11beta-HSD1 and 11beta-HSD2. 11beta-HSD1 functions as a dehydrogenase with no significant reverse reductase activity and colocalizes with cyclooxygenase COX-2 in proximal tubule cells. No colocalization of COX-2 with isoform 11beta-HSD2 in cortical collecting duct | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NAD+ | isoform 11beta-HSD2 | Homo sapiens | cortisone + NADH | - |
? | |
cortisol + NADP+ | - |
Homo sapiens | cortisone + NADPH | - |
? | |
cortisol + NADP+ | isoform 11beta-HSD1 | Homo sapiens | cortisone + NADPH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens |