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Literature summary for 1.1.1.146 extracted from

  • Yang, H.; Shen, Y.; Chen, J.; Jiang, Q.; Leng, Y.; Shen, J.
    Structure-based virtual screening for identification of novel 11beta-HSD1 inhibitors (2009), Eur. J. Med. Chem., 44, 1167-1171.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Mus musculus
expressed in HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(3E)-3-[[(4-bromo-3-methylphenoxy)acetyl]hydrazono]-N-tricyclo[3.3.1.13,7]dec-1-ylbutanamide
-
Homo sapiens
(3E)-3-[[(4-bromo-3-methylphenoxy)acetyl]hydrazono]-N-tricyclo[3.3.1.13,7]dec-1-ylbutanamide
-
Mus musculus
2-(2,4-dibromophenoxy)-N-[3-(1-hydroxyethyl)phenyl]propanamide
-
Homo sapiens
2-(2,4-dibromophenoxy)-N-[3-(1-hydroxyethyl)phenyl]propanamide
-
Mus musculus
3-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
-
Homo sapiens
3-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
-
Mus musculus
4-(1-benzofuran-2-ylcarbonyl)-5-(2-fluorophenyl)-3-hydroxy-1-[5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl]-1,5-dihydro-2H-pyrrol-2-one
-
Homo sapiens
4-(1-benzofuran-2-ylcarbonyl)-5-(2-fluorophenyl)-3-hydroxy-1-[5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl]-1,5-dihydro-2H-pyrrol-2-one
-
Mus musculus
4-(4-butoxy-3-methylbenzyl)-3-hydroxy-5-(4-methylphenyl)-1-(pyridin-3-ylmethyl)-1,5-dihydro-2H-pyrrol-2-one
-
Homo sapiens
4-(4-butoxy-3-methylbenzyl)-3-hydroxy-5-(4-methylphenyl)-1-(pyridin-3-ylmethyl)-1,5-dihydro-2H-pyrrol-2-one
-
Mus musculus
5-methyl-4-[(1E)-3-[(3-methylphenoxy)acetyl]triaz-1-en-1-yl]benzene-1,3-diol
-
Homo sapiens
5-methyl-4-[(1E)-3-[(3-methylphenoxy)acetyl]triaz-1-en-1-yl]benzene-1,3-diol
-
Mus musculus
enoxolone
-
Homo sapiens
enoxolone
-
Mus musculus
ethyl 5-[[(2,5-dimethylphenyl)sulfonyl]amino]-2-propyl-1-benzofuran-3-carboxylate
-
Homo sapiens
ethyl 5-[[(2,5-dimethylphenyl)sulfonyl]amino]-2-propyl-1-benzofuran-3-carboxylate
-
Mus musculus
N'-[(1E)-(5-bromo-2-hydroxyphenyl)methylidene]-2-([5-[(phenylamino)methyl]-4-prop-2-en-1-yl-4H-1,2,4-triazol-3-yl]sulfanyl)propanehydrazide
-
Homo sapiens
N'-[(1E)-(5-bromo-2-hydroxyphenyl)methylidene]-2-([5-[(phenylamino)methyl]-4-prop-2-en-1-yl-4H-1,2,4-triazol-3-yl]sulfanyl)propanehydrazide
-
Mus musculus
N'-[(1Z)-(2,4-dihydroxy-6-methylphenyl)methylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
Homo sapiens
N'-[(1Z)-(2,4-dihydroxy-6-methylphenyl)methylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
Mus musculus
N-(3-chloro-4-hydroxynaphthalen-1-yl)-2,4-dimethylbenzenesulfonamide
-
Homo sapiens
N-(3-chloro-4-hydroxynaphthalen-1-yl)-2,4-dimethylbenzenesulfonamide
-
Mus musculus
N-[(5-hydroxy-1,3,3-trimethylcyclohexyl)methyl]dibenzo[b,d]furan-2-sulfonamide
-
Homo sapiens
N-[(5-hydroxy-1,3,3-trimethylcyclohexyl)methyl]dibenzo[b,d]furan-2-sulfonamide
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Mus musculus
-
-
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P28845
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NADP+ the reaction is catalysed by 11beta-HSD2 Mus musculus cortisone + NADPH
-
?
cortisol + NADP+ the reaction is catalysed by 11beta-HSD2 Homo sapiens cortisone + NADPH
-
?
cortisone + NADPH + H+ reaction is catalysed by 11beta-HSD1 Mus musculus cortisol + NADP+
-
?
cortisone + NADPH + H+ reaction is catalysed by 11beta-HSD1 Homo sapiens cortisol + NADP+
-
?

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
Mus musculus
11beta-HSD1
-
Homo sapiens
11beta-HSD2
-
Mus musculus
11beta-HSD2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Mus musculus
NADP+
-
Homo sapiens
NADPH
-
Mus musculus
NADPH
-
Homo sapiens