Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cell | Mus musculus |
overexpressed in HEK-293 cell | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | - |
Homo sapiens | |
(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | - |
Mus musculus | |
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | - |
Homo sapiens | |
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | - |
Mus musculus | |
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one | - |
Homo sapiens | |
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one | - |
Mus musculus | |
glycyrrhizininc acid | - |
Homo sapiens | |
glycyrrhizininc acid | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | - |
Mus musculus | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxysteroid dehydrogenase 1 | - |
Mus musculus |
11beta-hydroxysteroid dehydrogenase 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Mus musculus | |
NADP+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
IC50 = 0.0017 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one | |
additional information | - |
IC50 = 0.0032 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | |
additional information | - |
IC50 = 0.008 mg/ml, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | |
additional information | - |
IC50 = 0.0107 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one | |
additional information | - |
IC50 = 0.0194 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | |
additional information | - |
IC50 = 0.0241 mg/ml, pH not specified in the publication, temperature not specified in the publication | Mus musculus | (4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol | |
0.0000186 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | glycyrrhizininc acid | |
0.0000295 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | glycyrrhizininc acid |