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Literature summary for 1.1.1.149 extracted from

  • Ishida, M.; Choi, J.H.; Hirabayashi, K.; Matsuwaki, T.; Suzuki, M.; Yamanouchi, K.; Horai, R.; Sudo, K.; Iwakura, Y.; Nishihara, M.
    Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene (2007), J. Reprod. Dev., 53, 499-508.
    View publication on PubMed

Application

Application Comment Organism
medicine targeted disruption of 20alpha-hydroxysteroid dehydrogenase gene results in complete loss of catalytic activity and lack of increase in serum concentrations of 20alpha-dihydroprogesterone during pseudopregnancy or pregnancy. The durations of the estrious cycle, pseudopregnancy, and pregnancy are significantly prolonged in the mutant mice, and the number of pups, espcially live pups, is markedly decreased Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information targeted disruption of 20alpha-hydroxysteroid dehydrogenase gene results in complete loss of catalytic activity and lack of increase in serum concentrations of 20alpha-dihydroprogesterone during pseudopregnancy or pregnancy. The durations of the estrious cycle, pseudopregnancy, and pregnancy are significantly prolonged in the mutant mice, and the number of pups, espcially live pups, is markedly decreased Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining