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Literature summary for 1.1.1.153 extracted from

  • Widder, J.D.; Chen, W.; Li, L.; Dikalov, S.; Thoeny, B.; Hatakeyama, K.; Harrison, D.G.
    Regulation of tetrahydrobiopterin biosynthesis by shear stress (2007), Circ. Res., 101, 830-838.
    View publication on PubMed
Search for more literature for 1.1.1.153

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme activity is not affected by laminar shear stress in endothelial cells, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme activity is not affected by laminar shear stress in endothelial cells, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH Homo sapiens
-
 tetrahydrobiopterin + NADP+
-
 r
additional information Homo sapiens the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis ?
-
 ?
sepiapterin + NADPH + H+ Homo sapiens
-
 7,8-dihydrobiopterin + NADP+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
-
 Homo sapiens tetrahydrobiopterin + NADP+
-
 r
additional information the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis Homo sapiens ?
-
 ?
sepiapterin + NADPH + H+
-
 Homo sapiens 7,8-dihydrobiopterin + NADP+
-
 r

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens
NADPH
-
 Homo sapiens