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Literature summary for 1.1.1.169 extracted from

  • Pei, X.; Wang, J.; Zheng, H.; Cheng, P.; Wu, Y.; Wang, A.; Su, W.
    Highly efficient asymmetric reduction of ketopantolactone to D-(-)-pantolactone by Escherichia coli cells expressing recombinant conjugated polyketone reductase and glucose dehydrogenase in a fed-batch biphasic reaction system (2020), React. Chem. Eng., 5, 531-538 .
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Cloned(Commentary)

Cloned (Comment) Organism
co-expressed with glucose dehydrogenase from Bacillus subtilis in Escherichia coli BL21(DE3) cells Candida dubliniensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ketopantolactone + NADPH + H+ Candida dubliniensis
-
 D-(-)-pantolactone + NADP+
-
 ?
ketopantolactone + NADPH + H+ Candida dubliniensis CD36
-
 D-(-)-pantolactone + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Candida dubliniensis
-
-
-
Candida dubliniensis CD36
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ketopantolactone + NADPH + H+
-
 Candida dubliniensis D-(-)-pantolactone + NADP+
-
 ?
ketopantolactone + NADPH + H+
-
 Candida dubliniensis CD36 D-(-)-pantolactone + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
conjugated polyketone reductase
-
 Candida dubliniensis
CPR
-
 Candida dubliniensis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
 Candida dubliniensis

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Candida dubliniensis