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Literature summary for 1.1.1.179 extracted from

  • Aoki, S.; Ishikura, S.; Asada, Y.; Usami, N.; Hara, A.
    Identity of dimeric dihydrodiol dehydrogenase as NADP+-dependent D-xylose dehydrogenase in pig liver (2001), Chem. Biol. Interact., 130-132, 775-784.
    View publication on PubMed
Search for more literature for 1.1.1.179

Activating Compound

Activating Compound Comment Organism Structure
KCl increase in activity about 2fold Sus scrofa
MgCl2 increase in activity about 4fold Sus scrofa
additional information
-
 Macaca fuscata
additional information higher salt concentration elevates the activity Sus scrofa

Protein Variants

Protein Variants Comment Organism
H79Q large increase in Km for coenzyme and substrates Macaca fuscata
Y180F
-
 Macaca fuscata

Inhibitors

Inhibitors Comment Organism Structure
high salt concentration recombinant H79Q mutant Macaca fuscata

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0011
-
 NADP+ + 20 mM MgCl2 Sus scrofa
1.3
-
 D-xylose 25 mM Tris + 20 mM MgCl2 Sus scrofa
6.4
-
 D-xylose
-
 Macaca fuscata
6.5
-
 D-xylose
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-xylose + NADP+ Homo sapiens
-
 D-xylono-1,5-lactone + NADPH + H+
-
 ?
D-xylose + NADP+ Sus scrofa
-
 D-xylono-1,5-lactone + NADPH + H+
-
 ?
D-xylose + NADP+ Oryctolagus cuniculus
-
 D-xylono-1,5-lactone + NADPH + H+
-
 ?
D-xylose + NADP+ Canis lupus familiaris
-
 D-xylono-1,5-lactone + NADPH + H+
-
 ?
D-xylose + NADP+ Macaca fuscata
-
 D-xylono-1,5-lactone + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-
Macaca fuscata
-
-
-
Oryctolagus cuniculus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa
-
 Oryctolagus cuniculus
-
 Canis lupus familiaris
-
 Macaca fuscata

Reaction

Reaction Comment Organism Reaction ID
D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH + H+ ordered bi-bi mechanism Sus scrofa
a

Source Tissue

Source Tissue Comment Organism Textmining
intestine exclusively Homo sapiens
-
kidney exclusively Macaca fuscata
-
lens
-
 Sus scrofa
-
lens
-
 Oryctolagus cuniculus
-
lens
-
 Canis lupus familiaris
-
liver
-
 Sus scrofa
-
liver
-
 Canis lupus familiaris
-
additional information enzyme activity is found in almost all tissues Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.6
-
-
 Sus scrofa
9
-
-
 Macaca fuscata

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-xylose + NADP+
-
 Homo sapiens D-xylono-1,5-lactone + NADPH + H+
-
 ?
D-xylose + NADP+
-
 Sus scrofa D-xylono-1,5-lactone + NADPH + H+
-
 ?
D-xylose + NADP+
-
 Oryctolagus cuniculus D-xylono-1,5-lactone + NADPH + H+
-
 ?
D-xylose + NADP+
-
 Canis lupus familiaris D-xylono-1,5-lactone + NADPH + H+
-
 ?
D-xylose + NADP+
-
 Macaca fuscata D-xylono-1,5-lactone + NADPH + H+
-
 ?
additional information
-
 Sus scrofa ?
-
 ?
additional information catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20 Homo sapiens ?
-
 ?
additional information catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20 Oryctolagus cuniculus ?
-
 ?
additional information catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20 Canis lupus familiaris ?
-
 ?
additional information catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20 Macaca fuscata ?
-
 ?
trans-benzene dihydrodiol + NADP+ dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 Sus scrofa ?
-
 ?
trans-benzene dihydrodiol + NADP+ dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 Oryctolagus cuniculus ?
-
 ?
trans-benzene dihydrodiol + NADP+ dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 Canis lupus familiaris ?
-
 ?
trans-benzene dihydrodiol + NADP+ dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 Macaca fuscata ?
-
 ?
trans-naphthalene dihydrodiol + NADP+ dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 Sus scrofa ?
-
 ?
trans-naphthalene dihydrodiol + NADP+ dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 Oryctolagus cuniculus ?
-
 ?
trans-naphthalene dihydrodiol + NADP+ dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 Canis lupus familiaris ?
-
 ?
trans-naphthalene dihydrodiol + NADP+ dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20 Macaca fuscata ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Sus scrofa
7.5
-
 assay at Oryctolagus cuniculus
7.5
-
 assay at Canis lupus familiaris
7.5
-
 assay at Macaca fuscata
10
-
 dihydrodiol dehydrogenase activity assay at Sus scrofa
10
-
 dihydrodiol dehydrogenase activity assay at Oryctolagus cuniculus
10
-
 dihydrodiol dehydrogenase activity assay at Canis lupus familiaris
10
-
 dihydrodiol dehydrogenase activity assay at Macaca fuscata

Cofactor

Cofactor Comment Organism Structure
additional information
-
 Sus scrofa
additional information Tyr71, His79, Lys97 involved in coenzyme binding Macaca fuscata
NADP+
-
 Homo sapiens
NADP+
-
 Sus scrofa
NADP+
-
 Oryctolagus cuniculus
NADP+
-
 Canis lupus familiaris
NADP+ Tyr71, His79, Lys97 involved in coenzyme binding Macaca fuscata