Literature summary for 1.1.1.188 extracted from

Grzesiak, M.; Knapczyk-Stwora, K.; Slomczynska, M.
The impact of flutamide on prostaglandin F2alpha synthase and prostaglandin F2alpha receptor expression, and prostaglandin F2alpha concentration in the porcine corpus luteum of pregnancy (2017), Domest. Anim. Endocrinol., 59, 81-89.

Search for more literature for 1.1.1.188

Cloned(Commentary)

Cloned (Comment)	Organism
gene AKR1B1, real-time PCR analysis enzyme expression	Sus scrofa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Sus scrofa	5737	-
additional information	on gestation day GD90 enzyme PGFS is immunolocalized in the cytoplasm of large luteal cells only, whereas on GD108, sparse small luteal cells also display positive staining. PTGF receptor shows membranous localization within large luteal cells on both days of pregnancy. Immunohistochemic analysis of enzyme and prostaglandin F2 receptor during geestation, overview	Sus scrofa	-	-

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-
Sus scrofa Large White x Polish Landrace	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
luteal cell	-	Sus scrofa	-
uterine endometrium	-	Sus scrofa	-

Synonyms

Synonyms	Comment	Organism
prostaglandin F2alpha synthase	-	Sus scrofa

Expression

Organism	Comment	Expression
Sus scrofa	flutamide, i.e. 2-methyl-N-[4-nitro-30-(trifluoromethyl)-phenyl]propamide, causes upregulation of enzyme PGFS mRNA and protein amount in pregnant female pigs at gestation days 90 and 108, whereas PTGF receptor protein expression is greater in both gestational periods	up

General Information

General Information	Comment	Organism
physiological function	prostaglandin F2alpha is the main luteolytic factor in pigs and its biosynthesis is catalyzed by prostaglandin F2alpha synthase, PGFS. The enzyme acts via specific seven-transmembrane G protein-coupled receptor (PTGFR) localized in large luteal cells. Intraluteal action of PGF2alpha causes a decrease in steroidogenic capacity and diminished production of progesterone. Intraluteal production of PGF2a is considered to be an important part of the luteolytic machinery	Sus scrofa

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)