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Literature summary for 1.1.1.188 extracted from

  • Garcia-Huertas, P.; Mejia-Jaramillo, A.M.; Machado, C.R.; Guimaraes, A.C.; Triana-Chavez, O.
    Prostaglandin F2alpha synthase in Trypanosoma cruzi plays critical roles in oxidative stress and susceptibility to benznidazole (2017), R. Soc. Open Sci., 4, 170773 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi Q4E4V7
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Trypanosoma cruzi CL Brener Q4E4V7
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Synonyms

Synonyms Comment Organism
Tc00.1047053508461.80
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 Trypanosoma cruzi

General Information

General Information Comment Organism
physiological function parasites overexpressing PGFS show alteration of enzymes associated with oxidative stress protection such as superoxide dismutase A and trypanothione reductase. Transfected parasites are approximately 2 times more susceptible to benznidazole and 10 times more susceptible to H2O2, and to genetic damage and oxidative stress. Transfected parasites are less infective than wild-type parasites and they show higher alteration in mitochondrial membrane potential and cell cycle after treatment with benznidazole Trypanosoma cruzi