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Literature summary for 1.1.1.189 extracted from

  • Wintergalen, N.; Thole, H.H.; Galla, H.J.; Schlegel, W.
    Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20.alpha-hydroxysteroid dehydrogenase activity (1995), Eur. J. Biochem., 234, 264-270.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
prostaglandin E2 inhibits the reduction of 20alpha-hydroxy-pregn-4-en-3-one to progesterone competitively Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0045
-
9,10-phenanthrenequinone
-
Oryctolagus cuniculus
0.0164
-
NADPH
-
Oryctolagus cuniculus
0.028
-
20alpha-hydroxy-pregn-4-en-3-one
-
Oryctolagus cuniculus
0.122
-
prostaglandin E2
-
Oryctolagus cuniculus
0.83
-
DL-glyceraldehyde
-
Oryctolagus cuniculus
1.1
-
methylglyoxal
-
Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Oryctolagus cuniculus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
gel filtration and SDS-PAGE Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
corpus luteum pseudopregnant rabbits Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.25
-
-
Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
Oryctolagus cuniculus (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
?
20alpha-hydroxy-pregn-4-en-3-one + NADP+
-
Oryctolagus cuniculus progesterone + NADPH
-
r
9,10-phenanthrenequinone + NADPH
-
Oryctolagus cuniculus ?
-
?
DL-glyceraldehyde + NADPH + H+
-
Oryctolagus cuniculus ?
-
r
methylglyoxal + NADPH + H+
-
Oryctolagus cuniculus ?
-
r

Subunits

Subunits Comment Organism
monomer alpha, 1 * 36000, SDS-PAGE Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Oryctolagus cuniculus
8
-
assay of 20alpha-hydroxy-pregn-4-en-3-one Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.025
-
prostaglandin E2 competitive inhibitor for the reduction of 20alpha-hydroxy-pregn-4-en-3-one to progesterone Oryctolagus cuniculus