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Literature summary for 1.1.1.19 extracted from

  • Goode, D.; Lewis, M.E.; Crabbe, M.J.C.
    Accumulation of xylitol in the mammalian lens is realted to glucoronate metabolism (1996), FEBS Lett., 395, 174-178.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
barbiturates
-
Bos taurus
Diphenylhydantoin
-
Bos taurus
N-ethylmaleimide no exact differentiation between organisms in the reference Bos taurus
N-ethylmaleimide no exact differentiation between organisms in the reference Rattus norvegicus
p-chloromercuribenzoate no exact differentiation between organisms in the reference Bos taurus
p-chloromercuribenzoate no exact differentiation between organisms in the reference Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0543
-
D-glucuronate no exact differentiation between organisms in the reference Rattus norvegicus
0.0543
-
D-glucuronate no exact differentiation between organisms in the reference Bos taurus
0.0543
-
D-glucuronate defined as D-glucuronate reductase Rattus norvegicus
0.0543
-
D-glucuronate defined as D-glucuronate reductase Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
2 * 36000, SDS-PAGE, no exact differentiation between organisms in the reference Rattus norvegicus
36000
-
2 * 36000, SDS-PAGE, no exact differentiation between organisms in the reference Bos taurus
60000 70000 no exact differentiation between organisms in the reference, gel filtration Rattus norvegicus
60000 70000 no exact differentiation between organisms in the reference, gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucuronate + NADPH Homo sapiens
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Rattus norvegicus
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Bos taurus
-
L-gulonate + NADP+
-
r
L-gulonate + NADP+ Homo sapiens
-
D-glucuronate + NADPH
-
r
L-gulonate + NADP+ Rattus norvegicus
-
D-glucuronate + NADPH
-
r
L-gulonate + NADP+ Bos taurus
-
D-glucuronate + NADPH
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
no exact differentiation between organisms in the reference Rattus norvegicus
no exact differentiation between organisms in the reference Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Homo sapiens
-
lens
-
Rattus norvegicus
-
lens
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0025
-
substrate D-glucuronate, defined as D-glucuronate reductase Rattus norvegicus
0.0025
-
substrate D-glucuronate, defined as D-glucuronate reductase Bos taurus
0.0025
-
no exact differentiation between organisms in the reference Rattus norvegicus
0.0025
-
no exact differentiation between organisms in the reference Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Bos taurus L-gulonate + NADP+
-
r
L-gulonate + NADP+
-
Homo sapiens D-glucuronate + NADPH
-
r
L-gulonate + NADP+
-
Rattus norvegicus D-glucuronate + NADPH
-
r
L-gulonate + NADP+
-
Bos taurus D-glucuronate + NADPH
-
r

Subunits

Subunits Comment Organism
dimer 2 * 36000, SDS-PAGE, no exact differentiation between organisms in the reference Rattus norvegicus
dimer 2 * 36000, SDS-PAGE, no exact differentiation between organisms in the reference Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
38
-
no exact differentiation between organisms in the reference Rattus norvegicus
38
-
no exact differentiation between organisms in the reference Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
no exact differentiation between organisms in the reference Rattus norvegicus
7.5
-
no exact differentiation between organisms in the reference Bos taurus

pH Stability

pH Stability pH Stability Maximum Comment Organism
8
-
no exact differentiation between organisms in the reference Rattus norvegicus
8
-
no exact differentiation between organisms in the reference Bos taurus
8
-
rapid decrease of activity above pH 8.0 Rattus norvegicus
8
-
rapid decrease of activity above pH 8.0 Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADP+
-
Rattus norvegicus
NADP+
-
Bos taurus
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus
NADPH
-
Bos taurus