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Literature summary for 1.1.1.195 extracted from

  • Liu, X.; Van Acker, R.; Voorend, W.; Pallidis, A.; Goeminne, G.; Pollier, J.; Morreel, K.; Kim, H.; Muylle, H.; Bosio, M.; Ralph, J.; Vanholme, R.; Boerjan, W.
    Rewired phenolic metabolism and improved saccharification efficiency of a Zea mays cinnamyl alcohol dehydrogenase 2 (zmcad2) mutant (2021), Plant J., 105, 1240-1257 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-coumaric aldehyde + NADPH + H+ Zea mays
-
4-coumaric alcohol + NADP+
-
?
cinnamyl aldehyde + NADPH + H+ Zea mays
-
cinnamyl alcohol + NADP+
-
?
coniferyl aldehyde + NADPH + H+ Zea mays
-
coniferyl alcohol + NADP+ ? ?
sinapyl aldehyde + NADPH + H+ Zea mays
-
sinapyl alcohol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Zea mays
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-coumaric aldehyde + NADPH + H+
-
Zea mays 4-coumaric alcohol + NADP+
-
?
cinnamyl aldehyde + NADPH + H+
-
Zea mays cinnamyl alcohol + NADP+
-
?
coniferyl aldehyde + NADPH + H+
-
Zea mays coniferyl alcohol + NADP+ ? ?
sinapyl aldehyde + NADPH + H+
-
Zea mays sinapyl alcohol + NADP+
-
?

Synonyms

Synonyms Comment Organism
CAD2
-
Zea mays
cinnamyl alcohol dehydrogenase 2
-
Zea mays

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Zea mays

General Information

General Information Comment Organism
malfunction isoform CAD2 downregulation improves saccharification efficiency. CAD2 enzyme-deficient mutants accumulate feruloyl and sinapoyl hexose conjugates. The total amount of lignin is reduced in the mutants, and only minor amounts of hydroxycinnamaldehydes are incorporated. Oligolignols composed of coniferyl and sinapyl alcohols are reduced, whereas those with one sinapaldehyde unit are increased in abundance in cad2 mutants Zea mays
physiological function the enzyme is involved in lignification Zea mays