Application | Comment | Organism |
---|---|---|
medicine | daunorubicin, a cancer chemotherapeutic agent can be reduced by aldehyde reductase | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP-ribose | competitive inhibition | Homo sapiens | |
diethyldicarbonate | kidney aldehyde reductase | Homo sapiens | |
NADP+ | competitive inhibition | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
L-glyceraldehyde + NADPH | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
succinic semialdehyde + NADPH + H+ | Homo sapiens | - |
4-hydroxybutyrate + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
daunorubicin + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
L-glyceraldehyde + NADPH | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
mevaldate + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
succinic semialdehyde + NADPH + H+ | - |
Homo sapiens | 4-hydroxybutyrate + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
3-acetylpyridine adenine dinucleotide phosphate | - |
Homo sapiens |