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Literature summary for 1.1.1.2 extracted from

  • El-Kabbani, O.; Carbone, V.; Darmanin, C.; Oka, M.; Mitschler, A.; Podjarny, A.; Schulze-Briese, C.; Chung, R.P.
    Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity (2005), J. Med. Chem., 48, 5536-5542.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop method, with NADPH, ammonium sulfate, Tris HCl-buffer, pH 8.1, buffer C, maximum side: 0.3 mm x 0.1 mm x 0,1 mm after 1 week Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
fidarestat interaction with the residues Tyr50, His113, Trp114 and Pro301 Sus scrofa
sorbinil
-
 Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH + H+
-
 Sus scrofa glycerol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
ALR1
-
 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Sus scrofa