Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(1,3,4-thiadiazol-2-yl)hex-4-enamide | 14.50% inhibition at 0.001 mg | Trypanosoma brucei brucei | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(1,3,4-thiadiazol-2-yl)hex-4-enamide | 4.59% inhibition at 0.001 mg | Trypanosoma congolense | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(1,3,4-thiadiazol-2-yl)hex-4-enamide | 29.44% inhibition at 0.001 mg | Trypanosoma evansi | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(1H-1,2,4-triazol-5-yl)hex-4-enamide | 46.13% inhibition at 0.001 mg | Trypanosoma brucei brucei | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(1H-1,2,4-triazol-5-yl)hex-4-enamide | 98.87% inhibition at 0.001 mg | Trypanosoma congolense | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(1H-1,2,4-triazol-5-yl)hex-4-enamide | 42.79% inhibition at 0.001 mg | Trypanosoma evansi | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(1H-tetrazol-5-yl)hex-4-enamide | 22.99% inhibition at 0.001 mg | Trypanosoma brucei brucei | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(1H-tetrazol-5-yl)hex-4-enamide | 3.59% inhibition at 0.001 mg | Trypanosoma congolense | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(1H-tetrazol-5-yl)hex-4-enamide | 19.94% inhibition at 0.001 mg | Trypanosoma evansi | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(4H-1,2,4-triazol-4-yl)hex-4-enamide | 14.29% inhibition at 0.001 mg | Trypanosoma brucei brucei | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(4H-1,2,4-triazol-4-yl)hex-4-enamide | 4.65% inhibition at 0.001 mg | Trypanosoma congolense | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(4H-1,2,4-triazol-4-yl)hex-4-enamide | 32.43% inhibition at 0.001 mg | Trypanosoma evansi | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(pyridin-2-yl)hex-4-enamide | 7.83% inhibition at 0.001 mg | Trypanosoma brucei brucei | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(pyridin-2-yl)hex-4-enamide | 2.36% inhibition at 0.001 mg | Trypanosoma congolense | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(pyridin-2-yl)hex-4-enamide | 16.66% inhibition at 0.001 mg | Trypanosoma evansi | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(thiazol-2-yl)hex-4-enamide | 22.27% inhibition at 0.001 mg | Trypanosoma brucei brucei | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(thiazol-2-yl)hex-4-enamide | 1.45% inhibition at 0.001 mg | Trypanosoma congolense | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-N-(thiazol-2-yl)hex-4-enamide | 17.11% inhibition at 0.001 mg | Trypanosoma evansi | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enethioic S-acid | 11.56% inhibition at 0.001 mg | Trypanosoma brucei brucei | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enethioic S-acid | 3.03% inhibition at 0.001 mg | Trypanosoma congolense | |
(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enethioic S-acid | 13.61% inhibition at 0.001 mg | Trypanosoma evansi | |
(E)-N-hydroxy-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamide | 5.24% inhibition at 0.001 mg | Trypanosoma brucei brucei | |
(E)-N-hydroxy-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamide | 94.46% inhibition at 0.001 mg | Trypanosoma congolense | |
(E)-N-hydroxy-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enamide | 14.21% inhibition at 0.001 mg | Trypanosoma evansi | |
(R,E)-7-hydroxy-5-methoxy-4-methyl-6-(3-methyl-6-(oxiran-2-yl)-6-oxohex-2-en-1-yl)isobenzofuran-1(3H)-one | 9.03% inhibition at 0.001 mg | Trypanosoma brucei brucei | |
(R,E)-7-hydroxy-5-methoxy-4-methyl-6-(3-methyl-6-(oxiran-2-yl)-6-oxohex-2-en-1-yl)isobenzofuran-1(3H)-one | 3.15% inhibition at 0.001 mg | Trypanosoma congolense | |
(R,E)-7-hydroxy-5-methoxy-4-methyl-6-(3-methyl-6-(oxiran-2-yl)-6-oxohex-2-en-1-yl)isobenzofuran-1(3H)-one | 9.49% inhibition at 0.001 mg | Trypanosoma evansi | |
(S,E)-7-hydroxy-5-methoxy-4-methyl-6-(3-methyl-6-(oxiran-2-yl)-6-oxohex-2-en-1-yl)isobenzofuran-1(3H)-one | 9.28% inhibition at 0.001 mg | Trypanosoma brucei brucei | |
(S,E)-7-hydroxy-5-methoxy-4-methyl-6-(3-methyl-6-(oxiran-2-yl)-6-oxohex-2-en-1-yl)isobenzofuran-1(3H)-one | 0.06% inhibition at 0.001 mg | Trypanosoma congolense | |
(S,E)-7-hydroxy-5-methoxy-4-methyl-6-(3-methyl-6-(oxiran-2-yl)-6-oxohex-2-en-1-yl)isobenzofuran-1(3H)-one | 11.99% inhibition at 0.001 mg | Trypanosoma evansi | |
Mycophenolic acid | 82.99% inhibition at 0.001 mg, inhibits the enzyme activity and leads to complete inhibition of proliferation of Trypanosoma at below 0.001 mM. Mycophenolic acid derivatives can act as trypanocidal drugs with trypanocidal activity | Trypanosoma brucei brucei | |
Mycophenolic acid | 99.60% inhibition at 0.001 mg, inhibits the enzyme activity and leads to complete inhibition of proliferation of Trypanosoma at below 0.001 mM. Mycophenolic acid derivatives can act as trypanocidal drugs with trypanocidal activity | Trypanosoma congolense | |
Mycophenolic acid | 90.53% inhibition at 0.001 mg, inhibits the enzyme activity and leads to complete inhibition of proliferation of Trypanosoma at below 0.001 mM. Mycophenolic acid derivatives can act as trypanocidal drugs with trypanocidal activity | Trypanosoma evansi | |
Pentamidine | complete inhibition at 500 ng/ml | Trypanosoma brucei brucei | |
Pentamidine | complete inhibition at 500 ng/ml | Trypanosoma congolense | |
Pentamidine | complete inhibition at 500 ng/ml | Trypanosoma evansi | |
S-(prop-1-en-2-yl) (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enethioate | 16.47% inhibition at 0.001 mg | Trypanosoma brucei brucei | |
S-(prop-1-en-2-yl) (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enethioate | 6.51% inhibition at 0.001 mg | Trypanosoma congolense | |
S-(prop-1-en-2-yl) (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enethioate | 12.79% inhibition at 0.001 mg | Trypanosoma evansi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei brucei | P50098 | - |
- |
Trypanosoma brucei brucei GUTat3.1 | P50098 | - |
- |
Trypanosoma congolense | A0A0S3MSA1 | - |
- |
Trypanosoma congolense IL3000 | A0A0S3MSA1 | - |
- |
Trypanosoma evansi | - |
- |
- |
Trypanosoma evansi Tansui | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
IMP dehydrogenase | - |
Trypanosoma evansi |
IMP dehydrogenase | - |
Trypanosoma congolense |
IMP dehydrogenase | - |
Trypanosoma brucei brucei |