Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1H-naphtho[2,3-d]imidazol-2-yl)methyl 4-aminobenzoate | - |
Helicobacter pylori | |
(1H-naphtho[2,3-d]imidazol-2-yl)methyl 4-aminobenzoate | - |
Homo sapiens | |
1-[(3,4-dichlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole | - |
Helicobacter pylori | |
1-[(3,4-dichlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole | 0.1% inhibition at 0.01 mM | Homo sapiens | |
1-[(3,4-dichlorophenyl)methyl]-4-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole | - |
Helicobacter pylori | |
1-[(3,4-dichlorophenyl)methyl]-4-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole | 0.1% inhibition at 0.01 mM | Homo sapiens | |
1-[(3-chlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole | - |
Helicobacter pylori | |
1-[(3-chlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole | 0.1% inhibition at 0.01 mM | Homo sapiens | |
1-[(3-chlorophenyl)methyl]-4-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole | - |
Helicobacter pylori | |
1-[(3-chlorophenyl)methyl]-4-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole | 0.1% inhibition at 0.01 mM | Homo sapiens | |
1-[(3-methoxyphenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole | - |
Helicobacter pylori | |
1-[(3-methoxyphenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole | 30.66% inhibition at 0.01 mM | Homo sapiens | |
1-[(3-methoxyphenyl)methyl]-4-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole | - |
Helicobacter pylori | |
1-[(3-methoxyphenyl)methyl]-4-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole | 24.94% inhibition at 0.01 mM | Homo sapiens | |
2-([2-[2-(furan-2-yl)phenyl]-4-oxo-4H-1-benzopyran-3-yl]oxy)-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | - |
Helicobacter pylori | |
2-([2-[2-(furan-2-yl)phenyl]-4-oxo-4H-1-benzopyran-3-yl]oxy)-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | 0.1% inhibition at 0.01 mM | Homo sapiens | |
2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide | - |
Helicobacter pylori | |
2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide | - |
Homo sapiens | |
2-[4-([1-[(3,4-dichlorophenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole | - |
Helicobacter pylori | |
2-[4-([1-[(3,4-dichlorophenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole | 0.1% inhibition at 0.01 mM | Homo sapiens | |
2-[4-([1-[(3-chlorophenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole | - |
Helicobacter pylori | |
2-[4-([1-[(3-chlorophenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole | 0.1% inhibition at 0.01 mM | Homo sapiens | |
2-[4-([1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole | - |
Helicobacter pylori | |
2-[4-([1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole | 0.1% inhibition at 0.01 mM | Homo sapiens | |
2-[[2-(2-chlorophenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | - |
Helicobacter pylori | |
2-[[2-(2-chlorophenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | 0.1% inhibition at 0.01 mM | Homo sapiens | |
2-[[2-(3,4-dimethoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | - |
Helicobacter pylori | |
2-[[2-(3,4-dimethoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | 34.45% inhibition at 0.01 mM | Homo sapiens | |
2-[[2-(3,4-dimethoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(naphthalen-1-yl)acetamide | - |
Helicobacter pylori | |
2-[[2-(3,4-dimethoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(naphthalen-1-yl)acetamide | 0.1% inhibition at 0.01 mM | Homo sapiens | |
2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | - |
Helicobacter pylori | |
2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | 56.81% inhibition at 0.01 mM | Homo sapiens | |
2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(naphthalen-1-yl)acetamide | - |
Helicobacter pylori | |
2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(naphthalen-1-yl)acetamide | 2.1% inhibition at 0.01 mM | Homo sapiens | |
2-[[2-(4-methylphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | - |
Helicobacter pylori | |
2-[[2-(4-methylphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | 0.1% inhibition at 0.01 mM | Homo sapiens | |
3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate | - |
Helicobacter pylori | |
3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate | - |
Homo sapiens | |
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate | - |
Helicobacter pylori | |
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate | - |
Homo sapiens | |
N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-([4-oxo-2-[2-(thiophen-2-yl)phenyl]-4H-1-benzopyran-3-yl]oxy)acetamide | - |
Helicobacter pylori | |
N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-([4-oxo-2-[2-(thiophen-2-yl)phenyl]-4H-1-benzopyran-3-yl]oxy)acetamide | 0.1% inhibition at 0.01 mM | Homo sapiens | |
N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-[[4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-3-yl]oxy]acetamide | - |
Helicobacter pylori | |
N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-[[4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-3-yl]oxy]acetamide | 0.1% inhibition at 0.01 mM | Homo sapiens | |
N-(4-bromophenyl)-2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]acetamide | - |
Helicobacter pylori | |
N-(4-bromophenyl)-2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]acetamide | 0.1% inhibition at 0.01 mM | Homo sapiens | |
N-(4-bromophenyl)-2-[[2-(4-methylphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]acetamide | - |
Helicobacter pylori | |
N-(4-bromophenyl)-2-[[2-(4-methylphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]acetamide | 0.1% inhibition at 0.01 mM | Homo sapiens | |
N-(4-chlorophenyl)-2-phenoxypropanamide | - |
Helicobacter pylori | |
N-(4-chlorophenyl)-2-phenoxypropanamide | - |
Homo sapiens | |
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide | - |
Helicobacter pylori | |
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide | - |
Homo sapiens | |
N-(4-methoxyphenyl)-2-(naphthalen-1-yl)acetamide | - |
Helicobacter pylori | |
N-(4-methoxyphenyl)-2-(naphthalen-1-yl)acetamide | - |
Homo sapiens | |
N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide | - |
Helicobacter pylori | |
N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide | - |
Homo sapiens | |
N-(naphthalen-1-yl)-2-[(4-oxo-2-phenyl-4H-1-benzopyran-3-yl)oxy]acetamide | - |
Helicobacter pylori | |
N-(naphthalen-1-yl)-2-[(4-oxo-2-phenyl-4H-1-benzopyran-3-yl)oxy]acetamide | 0.1% inhibition at 0.01 mM | Homo sapiens | |
N-(naphthalen-1-yl)-2-[[4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-3-yl]oxy]acetamide | - |
Helicobacter pylori | |
N-(naphthalen-1-yl)-2-[[4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-3-yl]oxy]acetamide | 16.54% inhibition at 0.01 mM | Homo sapiens | |
N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide | - |
Helicobacter pylori | |
N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide | C91, 0.197% inhibition at 0.01 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | Helicobacter pylori | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Homo sapiens | - |
XMP + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicobacter pylori | - |
- |
- |
Homo sapiens | P12268 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | - |
Helicobacter pylori | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Homo sapiens | XMP + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IMPDH | - |
Helicobacter pylori |
IMPDH2 | - |
Homo sapiens |
inosine 5'-monophosphate dehydrogenase | - |
Helicobacter pylori |
inosine 5'-monophosphate dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Helicobacter pylori | |
NAD+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00127 | - |
at pH 7.6 and 37°C | Helicobacter pylori | 1-[(3,4-dichlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole | |
0.00188 | - |
at pH 7.6 and 37°C | Helicobacter pylori | 2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | |
0.0021 | - |
at pH 7.6 and 37°C | Helicobacter pylori | 1-[(3-chlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole | |
0.00406 | - |
at pH 7.6 and 37°C | Helicobacter pylori | 2-[4-([1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole |