Any feedback?
Literature summary for 1.1.1.209 extracted from
- Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors (2008), Bioorg. Med. Chem., 16, 3245-3254.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chrysin | - |
Mus musculus |  |
| fidarestat | - |
Mus musculus | |
| minalrestat | inhibition pattern for AKR1C21, overview | Mus musculus | |
| additional information | enzyme-inhibitor complexe modelling, Tyr118 and Phe311 are important residues for inhibitor recognition and orientation in the active site of AKR1C21, overview | Mus musculus | |
| myricetin | - |
Mus musculus | |
| quercetin | inhibition pattern for AKR1C21, overview | Mus musculus | |
| quercitrin | - |
Mus musculus | |
| sorbinil | - |
Mus musculus | |
| Tolrestat | inhibition pattern for AKR1C21, overview | Mus musculus | |
| zopolrestat | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme catalyses the oxidoreduction of steroid hormones such as estrogens, androgens and neurosteroids | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme catalyses the oxidoreduction of steroid hormones such as estrogens, androgens and neurosteroids | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3(17)alpha-hydroxysteroid dehydrogenase | - |
Mus musculus |
| AKR1C21 | - |
Mus musculus |
| More | AKR1C21 is a member of the aldo-keto reductase superfamily | Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000009 | - |
pH 7.4, 25°C | Mus musculus | fidarestat | |
| 0.00003 | - |
pH 7.4, 25°C | Mus musculus | zopolrestat | |
| 0.00004 | - |
pH 7.4, 25°C | Mus musculus | Tolrestat | |
| 0.00007 | - |
pH 7.4, 25°C | Mus musculus | minalrestat | |
| 0.00015 | - |
pH 7.4, 25°C | Mus musculus | quercitrin | |
| 0.00091 | - |
pH 7.4, 25°C | Mus musculus | sorbinil | |
| 0.0022 | - |
pH 7.4, 25°C | Mus musculus | quercetin | |
| 0.0085 | - |
pH 7.4, 25°C | Mus musculus | chrysin | |
| 0.029 | - |
pH 7.4, 25°C | Mus musculus | myricetin | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
