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Literature summary for 1.1.1.21 extracted from

  • Tammali, R.; Ramana, K.V.; Singhal, S.S.; Awasthi, S.; Srivastava, S.K.
    Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin e2 production in human colon cancer cells (2006), Cancer Res., 66, 9705-9713.
    View publication on PubMed
Search for more literature for 1.1.1.21

Protein Variants

Protein Variants Comment Organism
additional information enzyme inhibition by antisense ablation with siRNA prevents fibroblast growth factor–induced and platelet-derived growth factor–induced up-regulation of PGE2 synthesis in Caco-2 cells, overview, nude mice bearing SW480 human colon adenocarcinoma cells completely arrest tumor progression Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
sorbinil enzyme inhibition abolishes fibroblast growth factor–induced and platelet-derived growth factor–induced up-regulation of PGE2 synthesis and lipid-adehyde signaling, e.g. by 4-hydroxy-trans-2-nonenal, in Caco-2 cells, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme reduces toxic lipid aldehydes and their conjugates with glutathione, besides reducing aldo-sugars efficiently, inhibition of AR prevents growth factor-induced COX-2 activity, reduces COX-2 protein and mRNA, and significantly decreases activation of nuclear factor-KB and protein kinase C, and phosphorylation of PKC-B2 as well as progression of Caco-2 cell growth but has no effect on COX-1 activity, reduces PGE2 synthesis and lipid-adehyde signaling, e.g. by 4-hydroxy-trans-2-nonenal, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell colon cancer cell line Homo sapiens
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HCT-116 cell colon cancer cell line Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme reduces toxic lipid aldehydes and their conjugates with glutathione, besides reducing aldo-sugars efficiently, inhibition of AR prevents growth factor-induced COX-2 activity, reduces COX-2 protein and mRNA, and significantly decreases activation of nuclear factor-KB and protein kinase C, and phosphorylation of PKC-B2 as well as progression of Caco-2 cell growth but has no effect on COX-1 activity, reduces PGE2 synthesis and lipid-adehyde signaling, e.g. by 4-hydroxy-trans-2-nonenal, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
aldose reductase
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 Homo sapiens