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Literature summary for 1.1.1.21 extracted from

  • Pladzyk, A.; Ramana, K.V.; Ansari, N.H.; Srivastava, S.K.
    Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells (2006), Exp. Eye Res., 83, 408-416.
    View publication on PubMed
Search for more literature for 1.1.1.21

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of the enzyme in lens epithelial cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme overexpression prevents the lipid aldehyde-induced activation of caspase-3, p38 MAPK, JNK, and the expression of Bcl-2 family proteins in lens epithelial cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
sorbinil in vivo inhibition potentiates apoptosis due to lipid aldehydes, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NADPH + H+ Homo sapiens the enzyme prevents lipid aldehyde-induced cytotoxicity leading to apoptosis in cultured lens epithelial cells, effects of diverse saturated and unsaturated aldehydes, overview alditol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell from lens Homo sapiens
-
lens cultured epithelial cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aldose + NADPH + H+
-
 Homo sapiens alditol + NADP+
-
 ?
aldose + NADPH + H+ the enzyme prevents lipid aldehyde-induced cytotoxicity leading to apoptosis in cultured lens epithelial cells, effects of diverse saturated and unsaturated aldehydes, overview Homo sapiens alditol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens