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Literature summary for 1.1.1.21 extracted from

  • Ramana, K.V.; Fadl, A.A.; Tammali, R.; Reddy, A.B.; Chopra, A.K.; Srivastava, S.K.
    Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages (2006), J. Biol. Chem., 281, 33019-33029.
    View publication on PubMed

Application

Application Comment Organism
medicine inhibition of AR may be a significant therapeutic approach in preventing bacterial endotoxin-induced sepsis and tissue damage Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of the aldehyde-metabolizing enzyme modulates NF-kappaB-dependent activation of inflammatory cytokines and chemokines in mouse serum, liver, heart, and spleen, overview Mus musculus
sorbinil
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NADPH + H+ Mus musculus the enzyme mediates the lipopolysaccharide-induced release of inflammatory mediators in macrophages, overview, inhibition of the aldehyde-metabolizing enzyme modulates NF-kappaB-dependent activation of inflammatory cytokines and chemokines in mouse serum, liver, heart, and spleen, overview alditol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Mus musculus
-
RAW-264.7 cell macrophage cell line Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aldose + NADPH + H+
-
Mus musculus alditol + NADP+
-
?
aldose + NADPH + H+ the enzyme mediates the lipopolysaccharide-induced release of inflammatory mediators in macrophages, overview, inhibition of the aldehyde-metabolizing enzyme modulates NF-kappaB-dependent activation of inflammatory cytokines and chemokines in mouse serum, liver, heart, and spleen, overview Mus musculus alditol + NADP+
-
?

Synonyms

Synonyms Comment Organism
AKR1B3
-
Mus musculus
aldose reductase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus