Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.21 extracted from

  • Jung, H.A.; Yoon, N.Y.; Kang, S.S.; Kim, Y.S.; Choi, J.S.
    Inhibitory activities of prenylated flavonoids from Sophora flavescens against aldose reductase and generation of advanced glycation endproducts (2008), J. Pharm. Pharmacol., 60, 1227-1236.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2'-methoxykurarinone potent inhibitor of rat lens aldose reductase Rattus norvegicus
(2S)-3beta,7,4'-trihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
-
Homo sapiens
(2S)-3beta,7,4'-trihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
-
Rattus norvegicus
(2S)-7,4'-dihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone potent inhibitor of recombinant human aldose reductase Homo sapiens
8-lavandulylkaempferol potent inhibitor of recombinant human aldose reductase Homo sapiens
8-lavandulylkaempferol potent inhibitor of rat lens aldose reductase Rattus norvegicus
desmethylanhydroicaritin potent inhibitor of recombinant human aldose reductase Homo sapiens
desmethylanhydroicaritin potent inhibitor of rat lens aldose reductase Rattus norvegicus
epalrestat
-
Homo sapiens
kuraridin potent inhibitor of recombinant human aldose reductase Homo sapiens
kurarinol potent inhibitor of rat lens aldose reductase Rattus norvegicus
kurarinone potent inhibitor of rat lens aldose reductase Rattus norvegicus
kushenol E potent inhibitor of recombinant human aldose reductase Homo sapiens
kushenol E potent inhibitor of rat lens aldose reductase Rattus norvegicus
quercetin potent inhibitor of recombinant human aldose reductase Homo sapiens
quercetin potent inhibitor of rat lens aldose reductase Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
aldose reductase
-
Homo sapiens
aldose reductase
-
Rattus norvegicus
RLAR
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00027
-
-
Homo sapiens kuraridin
0.00028
-
-
Homo sapiens epalrestat
0.00037
-
-
Homo sapiens (2S)-7,4'-dihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
0.00045
-
-
Homo sapiens desmethylanhydroicaritin
0.00079
-
-
Homo sapiens 8-lavandulylkaempferol
0.00085
-
-
Homo sapiens kushenol E
0.00095
-
-
Rattus norvegicus desmethylanhydroicaritin
0.00213
-
-
Rattus norvegicus kurarinol
0.00254
-
-
Homo sapiens quercetin
0.00299
-
-
Rattus norvegicus kurarinone
0.00363
-
-
Rattus norvegicus (2S)-3beta,7,4'-trihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
0.00377
-
-
Rattus norvegicus (2S)-2'-methoxykurarinone
0.0038
-
-
Rattus norvegicus 8-lavandulylkaempferol
0.00773
-
-
Rattus norvegicus quercetin
0.00774
-
-
Rattus norvegicus kushenol E