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Literature summary for 1.1.1.21 extracted from

  • Tammali, R.; Reddy, A.B.; Srivastava, S.K.; Ramana, K.V.
    Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo (2011), Angiogenesis, 14, 209-221.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
fidarestat aldose reductase inhibitor, attenuates the increase in growth, but in the absence of angiogenic factors, such as VEGF- and FGF, fidarestat alone does not affect the HUVEC growth Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
-
 Homo sapiens
-
endothelial cell
-
 Homo sapiens
-
HUVEC cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme inhibition prevents human colon cancer cell growth in culture as well as in nude mice xenografts. Inhibition of the enzyme also prevents angiogenic factors-induced invasion and migration of human umbilical vein endothelial cells and angiogenic factors-induced secretion/expression of ICAM, VCAM, MMP2, MMP9 and IL-6 in the cells, mechanisms, overview Homo sapiens
physiological function the enzyme is involved in oxidative stress signaling, it mediates colon cancer cell growth and proliferation involving angiogenic factors, such as VEGF- and FGF, overview Homo sapiens