Cloned (Comment) | Organism |
---|---|
expression in MCF-7 and HEK-293 cell | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-butyl-2-[[(4-oxo-3,4-dihydroquinazolin-2-yl)methyl]sulfanyl]-1H-benzimidazole-5-sulfonamide | classical competitive mechanism. No significant influence on 11beta-HSD activities | Homo sapiens | |
2-[(4-fluorobenzyl)[(2-fluorophenyl)sulfonyl]amino]-N-[2-(3-fluorophenyl)ethyl]acetamide | - |
Homo sapiens | |
methyl 3-methyl-2-([2-nitro-4-(trifluoromethyl)phenyl]amino)butanoate | - |
Homo sapiens | |
N-tert-butyl-2-(2-chloro-6-methoxy-4-([(3-methyl-5-sulfanyl-4H-1,2,4-triazol-4-yl)amino]methyl)phenoxy)acetamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P42330 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one + NADPH + H+ | fluorogenic synthetic substrate | Homo sapiens | ? + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17betaHSD5 | - |
Homo sapiens |
AKR1C3 | - |
Homo sapiens |
aldoketo reductase 1C3 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00029 | - |
pH 6.6, temperature not specified in the publication | Homo sapiens | 1-butyl-2-[[(4-oxo-3,4-dihydroquinazolin-2-yl)methyl]sulfanyl]-1H-benzimidazole-5-sulfonamide | |
0.001 | - |
pH 6.6, temperature not specified in the publication | Homo sapiens | N-tert-butyl-2-(2-chloro-6-methoxy-4-([(3-methyl-5-sulfanyl-4H-1,2,4-triazol-4-yl)amino]methyl)phenoxy)acetamide | |
0.0012 | - |
pH 6.6, temperature not specified in the publication | Homo sapiens | 2-[(4-fluorobenzyl)[(2-fluorophenyl)sulfonyl]amino]-N-[2-(3-fluorophenyl)ethyl]acetamide | |
0.00126 | - |
pH 6.6, temperature not specified in the publication | Homo sapiens | methyl 3-methyl-2-([2-nitro-4-(trifluoromethyl)phenyl]amino)butanoate |