Cloned (Comment) | Organism |
---|---|
recombinant expression of GFP-tagged enzyme in retina | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | recombinant enzyme overexpression elevates RMG activation in retina | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sorbinil | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P45376 | CX3CR1GFP mice carrying aldose reductase mutant alleles | - |
Mus musculus C57BL/6 | P45376 | CX3CR1GFP mice carrying aldose reductase mutant alleles | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | - |
Mus musculus | - |
microglia | from retinal cell | Mus musculus | - |
retina | whole retina and ocular tissue cryo sections | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
AKR1B1 | gene name, UniProt | Mus musculus |
aldose reductase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | lippolysaccharide, from Salmonella enterica serotype typhimurium, induces the enzyme in mouse retina | up |
General Information | Comment | Organism |
---|---|---|
malfunction | lipopolysacchride-induced RMG activation and migration into the inner nuclear layer or outer nuclear layer is largely prevented by enzyme inhibitors or in aldose reductase null mice, or is exacerbated in transgenic mice that over-express the enzyme | Mus musculus |
physiological function | aldose reductase regulates cytokine and chemokine production in the eye and mediates retinal microglia activation, role of the enzyme in RMG activation and migration in vivo, overview. Retinal microglia (RMG) are one of the major immune cells in charge of surveillance of inflammatory responses in the eye. In the absence of an inflammatory stimulus, RMG reside predominately in the ganglion layer and inner or outer plexiform layers. Under stress RMG become activated and migrate into the inner nuclear layer or outer nuclear layer. Activated RMG in cell culture secrete pro-inflammatory cytokines in a manner sensitive to downregulation by aldose reductase inhibitors. Aldose reductase expression in retinal microglia may contribute to the proinflammatory phenotypes common to various eye diseases such as uveitis and diabetic retinopathy | Mus musculus |