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Literature summary for 1.1.1.21 extracted from
- Aldose reductase modulates acute activation of mesenchymal markers via the beta-catenin pathway during cardiac ischemia-reperfusion (2017), PLoS ONE, 12, e0188981 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | mice devoid of AKR1B3 and exposed to acute occlusion of the left anterior descending coronary artery display reduced infarct size and improved functional recovery at 48 hours compared to wild-type mice. The cardioprotection observed in AKR1B3 null mice is linked to acute activation of the beta-catenin pathway and consequent activation of mesenchymal markers and genes linked to fibrotic remodeling. The increased activity of the beta-catenin pathway at 48 hours of recovery is not observed at 28 days post-infarction. In ex vivo studies, inhibition of beta-catenin blocks the cardioprotection observed in AKR1B3 null mice hearts | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AKR1B3 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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