Application | Comment | Organism |
---|---|---|
drug development | 2'-hydroxyflavanone may be useful for clinical therapy of malignancies where AKR1C3 is overexpressed like in prostate and breast cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
AKR1C3 PCR fragment cloned into pCR2.1-TOPO and then into vector pET15b and overexpressed in Escherichia coli strain BL21(DE3) | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-hydroxyflavanone | most potent inhibitor, 0.02 mM inhibits by 98.9% and in an uncompetitive manner | Homo sapiens | |
3-hydroxyflavone | - |
Homo sapiens | |
4'-hydroxyflavanone | - |
Homo sapiens | |
5-hydroxyflavone | - |
Homo sapiens | |
7-hydroxyflavone | very potent inhibitor, 0.02 mM inhibits by 82.5% | Homo sapiens | |
apigenin | 0.02 mM inhibits by ca. 50% | Homo sapiens | |
chlorogenic acid | - |
Homo sapiens | |
epigallocatechin gallate | - |
Homo sapiens | |
isovitexin | - |
Homo sapiens | |
luteolin | 0.02 mM inhibits by ca. 50% | Homo sapiens | |
additional information | is not inhibited by 0.02 mM caffeic acid, rutin, 4-hydroxybenzoic acid, cyanin chloride and taxifolin | Homo sapiens | |
naringenin | very potent inhibitor, 0.02 mM inhibits by 71.9% | Homo sapiens | |
quercetin | 0.02 mM inhibits by ca. 50% | Homo sapiens | |
silibinin | 0.02 mM inhibits by ca. 50% | Homo sapiens | |
vitexin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
oracin + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-hydroxysteroid dehydrogenase type 5 | - |
Homo sapiens |
3alpha-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
AKR1C3 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0003 | - |
- |
Homo sapiens | 2'-hydroxyflavanone | |
0.0024 | - |
- |
Homo sapiens | naringenin | |
0.0049 | - |
- |
Homo sapiens | 7-hydroxyflavone | |
0.0062 | - |
- |
Homo sapiens | silibinin | |
0.0188 | - |
- |
Homo sapiens | quercetin | |
0.0218 | - |
- |
Homo sapiens | apigenin | |
0.0374 | - |
- |
Homo sapiens | luteolin |