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Literature summary for 1.1.1.219 extracted from

  • Tian, J.; Han, Z.Y.; Zhang, J.; Hu, Y.; Song, T.; Yao, Y.
    The balance of expression of dihydroflavonol 4-reductase and flavonol synthase regulates flavonoid biosynthesis and red foliage coloration in crabapples (2015), Sci. Rep., 5, 12228 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Malus hybrid cultivar C3UZH2 cultivars Royalty (ever-red leaf cultivar) and Flame (ever-green leaf cultivar)
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Source Tissue

Source Tissue Comment Organism Textmining
fruit
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 Malus hybrid cultivar
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leaf
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 Malus hybrid cultivar
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Synonyms

Synonyms Comment Organism
McDFR
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 Malus hybrid cultivar

Expression

Organism Comment Expression
Malus hybrid cultivar anthocyanin levels shows a positive correlation with the expression of dihydroflavonol 4-reductase. Down-regulation of dihydroflavonol 4-reductase expression results in fading leaf color down
Malus hybrid cultivar anthocyanin levels shows a positive correlation with the expression of dihydroflavonol 4-reductase up

General Information

General Information Comment Organism
physiological function the concentrations of anthocyanins and flavonols correlates with leaf color. It is proposed that the expression of dihydroflavonol 4-reductase and flavonol synthase influences their accumulation. Overexpression of dihydroflavonol 4-reductase, or silencing of flavonol synthase, increases anthocyanin production, resulting in red-leaf and red fruit peel phenotypes. Conversely, elevated flavonol production and green phenotypes in crabapple leaves and apple peel are observed when dihydroflavonol 4-reductase is overexpressed or dihydroflavonol 4-reductase is silenced. These results suggest that the relative activities of dihydroflavonol 4-reductase and flavonol synthase are important determinants of the red color of crabapple leaves, via the regulation of the metabolic fate of substrates that these enzymes have in common Malus hybrid cultivar