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Literature summary for 1.1.1.22 extracted from

  • Sheng, J.Z.; Ling, P.X.; Zhu, X.Q.; Guo, X.P.; Zhang, T.M.; He, Y.L.; Wang, F.S.
    Use of induction promoters to regulate hyaluronan synthase and UDP-glucose-6-dehydrogenase of Streptococcus zooepidemicus expression in Lactococcus lactis: a case study of the regulation mechanism of hyaluronic acid polymer (2009), J. Appl. Microbiol., 107, 136-144.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
lactose UDP-GlcDH activities in extracts of Lactococcus lactis strain NFHA01 induced with both 0.5% and 2% lactose are significantly higher than that of the same strain without induction. UDP-GlcDH activity of NFHA01 induced with 2% lactose is about 110% higher than that of 0.5% lactose induction Streptococcus equi subsp. zooepidemicus
nisin induces the expression of szHasA together with szHasB Streptococcus equi subsp. zooepidemicus

Cloned(Commentary)

Cloned (Comment) Organism
genes szHasA (hyaluronan synthase gene) and szHasB (UDP-glucose-6-dehydrogenase gene) introduced into Lactococcus lactis strain NZ9000 under the control of nisA promoter and lacA promoter respectively, resulting in a dual-plasmid controlled expression system Streptococcus equi subsp. zooepidemicus

Organism

Organism UniProt Comment Textmining
Streptococcus equi subsp. zooepidemicus
-
 FHA0
-
Streptococcus equi subsp. zooepidemicus FHA0
-
 FHA0
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + 2 NAD+ + H2O
-
 Streptococcus equi subsp. zooepidemicus UDP-glucuronate + 2 NADH + 2 H+
-
 ?
UDP-glucose + 2 NAD+ + H2O
-
 Streptococcus equi subsp. zooepidemicus FHA0 UDP-glucuronate + 2 NADH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
UDP-GlcDH
-
 Streptococcus equi subsp. zooepidemicus
UDP-glucose dehydrogenase
-
 Streptococcus equi subsp. zooepidemicus