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Literature summary for 1.1.1.223 extracted from

  • Sato-Masumoto, N.; Ito, M.
    Isolation and characterization of isopiperitenol dehydrogenase from piperitenone-type Perilla (2014), Biol. Pharm. Bull., 37, 847-852.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene PK-ISPD1, DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of His-tagged enzyme in Escherichia coli strain TOP10F' Perilla frutescens var. hirtella
gene PT-ISPD2, DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of His-tagged enzyme in Escherichia coli strain TOP10F' Perilla frutescens
gene PT-ISPD2, DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of His-tagged enzyme in Escherichia coli strain TOP10F' Perilla frutescens var. hirtella

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(-)-cis-isopiperitenol + NAD+ Perilla frutescens var. hirtella
-
(-)-isopiperitenone + NADH + H+
-
r
(-)-cis-isopiperitenol + NAD+ Perilla frutescens
-
(-)-isopiperitenone + NADH + H+
-
ir
(-)-cis-isopiperitenol + NAD+ Perilla frutescens var. hirtella
-
(-)-isopiperitenone + NADH + H+
-
ir
(-)-cis-isopiperitenol + NAD+ Perilla frutescens 5598
-
(-)-isopiperitenone + NADH + H+
-
ir
(-)-cis-isopiperitenol + NAD+ Perilla frutescens var. hirtella 5712
-
(-)-isopiperitenone + NADH + H+
-
ir
(-)-cis-isopiperitenol + NAD+ Perilla frutescens var. hirtella 5712
-
(-)-isopiperitenone + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Perilla frutescens W5VJJ6 PT-type
-
Perilla frutescens 5598 W5VJJ6 PT-type
-
Perilla frutescens var. hirtella W5VJM4
-
-
Perilla frutescens var. hirtella W5VJT8 PK-type, not found in not found in PT-type strains nos. 5598 and 5601
-
Perilla frutescens var. hirtella 5712 W5VJM4
-
-
Perilla frutescens var. hirtella 5712 W5VJT8 PK-type, not found in not found in PT-type strains nos. 5598 and 5601
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged enzyme from Escherichia coli strain TOP10F' Perilla frutescens var. hirtella
recombinant His-tagged enzyme from Escherichia coli strain TOP10F' Perilla frutescens

Source Tissue

Source Tissue Comment Organism Textmining
leaf young Perilla frutescens var. hirtella
-
leaf young Perilla frutescens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(-)-cis-isopiperitenol + NAD+
-
Perilla frutescens var. hirtella (-)-isopiperitenone + NADH + H+
-
r
(-)-cis-isopiperitenol + NAD+
-
Perilla frutescens (-)-isopiperitenone + NADH + H+
-
ir
(-)-cis-isopiperitenol + NAD+
-
Perilla frutescens var. hirtella (-)-isopiperitenone + NADH + H+
-
ir
(-)-cis-isopiperitenol + NAD+
-
Perilla frutescens 5598 (-)-isopiperitenone + NADH + H+
-
ir
(-)-cis-isopiperitenol + NAD+
-
Perilla frutescens var. hirtella 5712 (-)-isopiperitenone + NADH + H+
-
ir
(-)-cis-isopiperitenol + NAD+
-
Perilla frutescens var. hirtella 5712 (-)-isopiperitenone + NADH + H+
-
r
(-)-trans-isopiperitenol + NAD+
-
Perilla frutescens var. hirtella (-)-isopiperitenone + NADH + H+
-
r
(-)-trans-isopiperitenol + NAD+
-
Perilla frutescens var. hirtella 5712 (-)-isopiperitenone + NADH + H+
-
r
additional information ISPD1 has broader substrate specificity than ISPD2 Perilla frutescens var. hirtella ?
-
?
additional information ISPD2 has a greater substrate specificity compared to ISPD1 Perilla frutescens ?
-
?
additional information ISPD2 has a greater substrate specificity compared to ISPD1 Perilla frutescens var. hirtella ?
-
?
additional information ISPD2 has a greater substrate specificity compared to ISPD1 Perilla frutescens 5598 ?
-
?
additional information ISPD2 has a greater substrate specificity compared to ISPD1 Perilla frutescens var. hirtella 5712 ?
-
?
additional information ISPD1 has broader substrate specificity than ISPD2 Perilla frutescens var. hirtella 5712 ?
-
?

Synonyms

Synonyms Comment Organism
isopiperitenol dehydrogenase 1
-
Perilla frutescens var. hirtella
isopiperitenol dehydrogenase 2
-
Perilla frutescens
isopiperitenol dehydrogenase 2
-
Perilla frutescens var. hirtella
ISPD1
-
Perilla frutescens var. hirtella
ISPD2
-
Perilla frutescens
ISPD2
-
Perilla frutescens var. hirtella
PK-ISPD1
-
Perilla frutescens var. hirtella
PK-ISPD2
-
Perilla frutescens var. hirtella
PT-ISPD2
-
Perilla frutescens
PT-ISPD2
-
Perilla frutescens var. hirtella

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Perilla frutescens var. hirtella
NAD+
-
Perilla frutescens
NADH
-
Perilla frutescens var. hirtella

General Information

General Information Comment Organism
metabolism the enzyme is involved in the biosynthetic pathways of oil constituents (PA-type, PT-type, and PK-type) in Perilla, putative pathways, overview Perilla frutescens var. hirtella
metabolism the enzyme is involved in the biosynthetic pathways of oil constituents (PA-type, PT-type, and PK-type) in Perilla, putative pathways, overview. (-)-cis-Isopiperitenol is an intermediate for the piperitenone biosynthesis of perilla Perilla frutescens
metabolism the enzyme is involved in the biosynthetic pathways of oil constituents (PA-type, PT-type, and PK-type) in Perilla, putative pathways, overview. (-)-cis-Isopiperitenol is an intermediate for the piperitenone biosynthesis of perilla Perilla frutescens var. hirtella
physiological function isozyme ISPD1 is less likely to be involved in oxidation of isopiperitenol Perilla frutescens var. hirtella
physiological function isozyme ISPD2 is likely to be involved in oxidation of isopiperitenol Perilla frutescens
physiological function isozyme ISPD2 is likely to be involved in oxidation of isopiperitenol Perilla frutescens var. hirtella