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Literature summary for 1.1.1.232 extracted from

  • Sok, D.E.; Kang, J.B.; Shin, H.D.
    15-Hydroxyeicosatetraenoic acid dehydrogenase activity in microsomal fraction of mouse liver homogenate (1988), Biochem. Biophys. Res. Commun., 156, 524-529.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0083
-
(15S)-15-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
-
Mus musculus
0.06
-
NAD+
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome tightly bound to membranes Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Storage Stability

Storage Stability Organism
4Ā°C enzyme in microsomal fraction very stable, cytosolic and mitochondrial fractions more than 90% loss of activity within 1 day Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(15S)-15-hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + NAD(P)+
-
Mus musculus 15-oxo-5,8,11-cis-13-trans-eicosatetraenoate + NAD(P)H
-
?
15(S)-15-hydroxy-5,8,11-cis-13-trans-icosatetranoate + NAD+
-
Mus musculus 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NADH + H+
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.8
-
-
Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
7.6 11.2
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+ almost the same reaction rates with NAD+ and NADP+ Mus musculus
NADP+ almost the same reaction rates with NAD+ and NADP+ Mus musculus