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Literature summary for 1.1.1.248 extracted from
- Systematic knockdown of morphine pathway enzymes in opium poppy using virus-induced gene silencing (2012), Plant J., 69, 1052-1063.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| real-time quantitative PCR expression analysis | Papaver somniferum |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | specific virus-induced gene silencing as a functional genomics tool to investigate the regulation of morphine biosynthesis via a systematic reduction in enzyme levels responsible for the final six steps in the pathway, overview. Reduced SalR protein levels correlate with lower morphine levels and a substantial increase in the accumulation of salutaridine | Papaver somniferum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| salutaridine + NADPH + H+ | Papaver somniferum | - |
salutaridinol + NADP+ | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Papaver somniferum | - |
gene salR | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| salutaridine + NADPH + H+ | - |
Papaver somniferum | salutaridinol + NADP+ | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SalR | - |
Papaver somniferum |
| salutaridine reductase | - |
Papaver somniferum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Papaver somniferum | |
| NADPH | - |
Papaver somniferum | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | reduced SalR protein levels correlate with lower morphine levels and a substantial increase in the accumulation of salutaridine. Morphine biosynthesis can be perturbed at each of the six final steps | Papaver somniferum |
| metabolism | the enzyme catalyzes a step in the morphinan alkaloid pathway, benzylisoquinoline alkaloid biosynthesis in opium poppy from (R)-reticuline to morphine overview. Morphine biosynthesis can be perturbed at each of the six final steps | Papaver somniferum |
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Release 2023.1 (January 2023)
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