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Literature summary for extracted from

  • Warringer, J.; Blomberg, A.
    Involvement of yeast YOL151W/GRE2 in ergosterol metabolism (2006), Yeast, 23, 389-398.
    View publication on PubMed


Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q12068


Synonyms Comment Organism
Saccharomyces cerevisiae
Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function in strains lacking Gre2 activity, which are subjected to environmental stress straining the cell membrane, growth is significantly and exclusively reduced. No compensatory mechanisms are activated due to loss of Gre2p during growth in favourable conditions (synthetic defined media, no stress), but a striking and highly specific induction of the ergosterol biosynthesis pathway, enzymes Erg10, Erg19 and Erg6, is observed in Gre2 mutant strains during growth in a stress conditions in which lack of Gre2 significantly affects growth. Mutant strains display vastly impaired tolerance exclusively to agents targeting the ergosterol biosynthesis Saccharomyces cerevisiae