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Literature summary for 1.1.1.267 extracted from

  • Woo, Y.H.; Fernandes, R.P.; Proteau, P.J.
    Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase (2006), Bioorg. Med. Chem., 14, 2375-2385.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a target for antibacterial agents and inhibitor design Synechocystis sp.

Inhibitors

Inhibitors Comment Organism Structure
4-(N-formyl-N-hydroxy-amino)-butyric acid
-
Synechocystis sp.
fosfoxacin phosphate analogue of fosmidomycin Synechocystis sp.
fosmidomycin
-
Synechocystis sp.
FR900098 N-acetyl analogue of fosmidomycin Synechocystis sp.
phosphoric acid mono-[2-(N-acetyl-N-hydroxy-amino)-ethyl]-ester
-
Synechocystis sp.
sulfamic acid 2-(N-formyl-N-hydroxy-amino)-ethyl ester
-
Synechocystis sp.
[3-(N-acetyl-N-methyl-amino)propyl]-phosphonic acid
-
Synechocystis sp.
[3-(N-formyl-N-methyl-amino)-propyl]-phosphonic acid
-
Synechocystis sp.
[4-(hydroxyamino)-4-oxobutyl]phosphonic acid
-
Synechocystis sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ a divalent metal ion is absolutely required for activity, involved in catalysis Synechocystis sp.
Mn2+ a divalent metal ion is absolutely required for activity, involved in catalysis Synechocystis sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ Synechocystis sp. step in the methylerythritol 4-phosphate pathway 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Synechocystis sp.
-
strain PCC6803
-

Reaction

Reaction Comment Organism Reaction ID
2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ reaction mechanism via 2-C-methylerythrose 4-phosphate intermediate Synechocystis sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ step in the methylerythritol 4-phosphate pathway Synechocystis sp. 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
?
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ i.e. DXP Synechocystis sp. 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
?

Synonyms

Synonyms Comment Organism
1-deoxy-D-xylulose 5-phosphate reductoisomerase
-
Synechocystis sp.
DXR
-
Synechocystis sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Synechocystis sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Synechocystis sp.

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Synechocystis sp.

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000002
-
phosphoric acid mono-[2-(N-acetyl-N-hydroxy-amino)-ethyl]-ester pH 7.5, 37°C Synechocystis sp.
0.000019
-
fosfoxacin pH 7.5, 37°C Synechocystis sp.
0.000057
-
fosmidomycin pH 7.5, 37°C Synechocystis sp.
0.0009
-
FR900098 pH 7.5, 37°C Synechocystis sp.
0.24
-
4-(N-formyl-N-hydroxy-amino)-butyric acid pH 7.5, 37°C Synechocystis sp.
2.4
-
[4-(hydroxyamino)-4-oxobutyl]phosphonic acid pH 7.5, 37°C Synechocystis sp.
2.8
-
sulfamic acid 2-(N-formyl-N-hydroxy-amino)-ethyl ester pH 7.5, 37°C Synechocystis sp.
3.6
-
[3-(N-acetyl-N-methyl-amino)propyl]-phosphonic acid pH 7.5, 37°C Synechocystis sp.
5
-
[3-(N-formyl-N-methyl-amino)-propyl]-phosphonic acid pH 7.5, 37°C Synechocystis sp.