Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for antibacterial agents and inhibitor design | Synechocystis sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(N-formyl-N-hydroxy-amino)-butyric acid | - |
Synechocystis sp. | |
fosfoxacin | phosphate analogue of fosmidomycin | Synechocystis sp. | |
fosmidomycin | - |
Synechocystis sp. | |
FR900098 | N-acetyl analogue of fosmidomycin | Synechocystis sp. | |
phosphoric acid mono-[2-(N-acetyl-N-hydroxy-amino)-ethyl]-ester | - |
Synechocystis sp. | |
sulfamic acid 2-(N-formyl-N-hydroxy-amino)-ethyl ester | - |
Synechocystis sp. | |
[3-(N-acetyl-N-methyl-amino)propyl]-phosphonic acid | - |
Synechocystis sp. | |
[3-(N-formyl-N-methyl-amino)-propyl]-phosphonic acid | - |
Synechocystis sp. | |
[4-(hydroxyamino)-4-oxobutyl]phosphonic acid | - |
Synechocystis sp. |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | a divalent metal ion is absolutely required for activity, involved in catalysis | Synechocystis sp. | |
Mn2+ | a divalent metal ion is absolutely required for activity, involved in catalysis | Synechocystis sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | Synechocystis sp. | step in the methylerythritol 4-phosphate pathway | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Synechocystis sp. | - |
strain PCC6803 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | reaction mechanism via 2-C-methylerythrose 4-phosphate intermediate | Synechocystis sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | step in the methylerythritol 4-phosphate pathway | Synechocystis sp. | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | i.e. DXP | Synechocystis sp. | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
1-deoxy-D-xylulose 5-phosphate reductoisomerase | - |
Synechocystis sp. |
DXR | - |
Synechocystis sp. |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Synechocystis sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Synechocystis sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Synechocystis sp. |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000002 | - |
phosphoric acid mono-[2-(N-acetyl-N-hydroxy-amino)-ethyl]-ester | pH 7.5, 37°C | Synechocystis sp. | |
0.000019 | - |
fosfoxacin | pH 7.5, 37°C | Synechocystis sp. | |
0.000057 | - |
fosmidomycin | pH 7.5, 37°C | Synechocystis sp. | |
0.0009 | - |
FR900098 | pH 7.5, 37°C | Synechocystis sp. | |
0.24 | - |
4-(N-formyl-N-hydroxy-amino)-butyric acid | pH 7.5, 37°C | Synechocystis sp. | |
2.4 | - |
[4-(hydroxyamino)-4-oxobutyl]phosphonic acid | pH 7.5, 37°C | Synechocystis sp. | |
2.8 | - |
sulfamic acid 2-(N-formyl-N-hydroxy-amino)-ethyl ester | pH 7.5, 37°C | Synechocystis sp. | |
3.6 | - |
[3-(N-acetyl-N-methyl-amino)propyl]-phosphonic acid | pH 7.5, 37°C | Synechocystis sp. | |
5 | - |
[3-(N-formyl-N-methyl-amino)-propyl]-phosphonic acid | pH 7.5, 37°C | Synechocystis sp. |