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Literature summary for 1.1.1.267 extracted from
- Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin (2007), Acta Crystallogr. Sect. F, F63, 466-470.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| in complex with Mg2+, NADPH, and inhibitor fosmidomycin. Protein exhibits a well-ordered conformation upon substrate binding. No electron density is observed for the nicotinamide-ribose portion of NADPH and the position of D149 anchoring Mg2+ is shifted by NADPH in the active site | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| fosmidomycin | - |
Escherichia coli |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P45568 | - |
- |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Escherichia coli | |
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