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Literature summary for 1.1.1.267 extracted from
- Molecular epidemiology of malaria in Cameroon. XXV. In vitro activity of fosmidomycin and its derivatives against fresh clinical isolates of Plasmodium falciparum and sequence analysis of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (2007), Am. J. Trop. Med. Hyg., 77, 214-220.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | 50% inhibition of growth of parasite in cultured infected erythrocytes is 2-3 times lower with fetal bovine serum in the culture liquide than with human serum | Plasmodium falciparum |
| medicine | study on inhibitory effect of antimalarial drugs in clinical isolates of Plasmodium falciparum. No correlation between chloroquine or pyrimethamine and fosmidomycin. Fosmidomycin is moderately active against both chloroquine-susceptible and chloroquine-resistant isolates | Plasmodium falciparum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Chloroquine | - |
Plasmodium falciparum |  |
| fosmidomycin | analysis of parasite growth in infected cultured erythrocytes. 50% growth inhibition at about 301 nM | Plasmodium falciparum | |
| FR900098 | analysis of parasite growth in infected cultured erythrocytes. 50% growth inhibition at about 118 nM | Plasmodium falciparum | |
| pyrimethamine | - |
Plasmodium falciparum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium falciparum | O96693 | clinical isolates | - |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000301 | - |
- |
Plasmodium falciparum | fosmidomycin | |
| 0.118 | - |
- |
Plasmodium falciparum | FR900098 | |
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